Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II).
someric bidentate ligands having nitrogen–sulfur donor sequence were prepared by condensing S-benzyldithiocarbazate (SBDTC) with 5-methyl-2-furyladehyde (NS) and 2-furylmethylketone (NS′). Complexes of these ligands with lead, tin, iron, cobalt and cadmium gave complexes of [M(L)2] (M=Pb, Fe and Cd)...
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| Format: | Article |
| Language: | English English English |
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Elsevier
2002
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25095/ http://psasir.upm.edu.my/id/eprint/25095/1/Coordination%20chemistry%20and%20bioactivity%20of%20some%20metal%20complexes%20containing%20two%20isomeric%20bidentate%20NS%20schiff%20bases%20derived%20from%20S.pdf http://psasir.upm.edu.my/id/eprint/25095/7/1-s2.0-S027753870201272X-main.pdf |
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| author | Tarafder, M.T.H. Khoo, Teng Jin Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.K. |
| author_facet | Tarafder, M.T.H. Khoo, Teng Jin Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.K. |
| author_sort | Tarafder, M.T.H. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | someric bidentate ligands having nitrogen–sulfur donor sequence were prepared by condensing S-benzyldithiocarbazate (SBDTC) with 5-methyl-2-furyladehyde (NS) and 2-furylmethylketone (NS′). Complexes of these ligands with lead, tin, iron, cobalt and cadmium gave complexes of [M(L)2] (M=Pb, Fe and Cd) and [M(L)2]Cln (M=Sn, n=2 and Co, n=1) (L=NS and NS′). The compounds have been characterized by spectroscopic studies (infrared, 1H NMR and electronic spectra). X-ray crystallographic analysis of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate shows the presence of two independent molecules in the asymmetric unit. The molecule adopts a trans–cis configuration, as was observed in other analogues, such as SBDTC where the furylmethylene and benzyl groups are trans and cis about the N-C and C-S bonds, respectively. The molecular structure of bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II) shows a tetrahedral geometry about the central cadmium atom with the bidentate ligand coordinating through the thioketo sulfur and the azomethine nitrogen atoms. The lead(II) complex of the NS ligand was highly cytotoxic against leukemic cells (CEM-SS) with a CD50 of 3.25 μg cm−3 while antimicrobial screening showed that the [Fe(NS)2]Cl2·H2O complex was effective against Aspergillus achraceous. |
| first_indexed | 2025-11-15T08:43:17Z |
| format | Article |
| id | upm-25095 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-15T08:43:17Z |
| publishDate | 2002 |
| publisher | Elsevier |
| recordtype | eprints |
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| spelling | upm-250952024-07-24T07:37:45Z http://psasir.upm.edu.my/id/eprint/25095/ Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). Tarafder, M.T.H. Khoo, Teng Jin Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.K. someric bidentate ligands having nitrogen–sulfur donor sequence were prepared by condensing S-benzyldithiocarbazate (SBDTC) with 5-methyl-2-furyladehyde (NS) and 2-furylmethylketone (NS′). Complexes of these ligands with lead, tin, iron, cobalt and cadmium gave complexes of [M(L)2] (M=Pb, Fe and Cd) and [M(L)2]Cln (M=Sn, n=2 and Co, n=1) (L=NS and NS′). The compounds have been characterized by spectroscopic studies (infrared, 1H NMR and electronic spectra). X-ray crystallographic analysis of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate shows the presence of two independent molecules in the asymmetric unit. The molecule adopts a trans–cis configuration, as was observed in other analogues, such as SBDTC where the furylmethylene and benzyl groups are trans and cis about the N-C and C-S bonds, respectively. The molecular structure of bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II) shows a tetrahedral geometry about the central cadmium atom with the bidentate ligand coordinating through the thioketo sulfur and the azomethine nitrogen atoms. The lead(II) complex of the NS ligand was highly cytotoxic against leukemic cells (CEM-SS) with a CD50 of 3.25 μg cm−3 while antimicrobial screening showed that the [Fe(NS)2]Cl2·H2O complex was effective against Aspergillus achraceous. Elsevier 2002 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/25095/1/Coordination%20chemistry%20and%20bioactivity%20of%20some%20metal%20complexes%20containing%20two%20isomeric%20bidentate%20NS%20schiff%20bases%20derived%20from%20S.pdf text en http://psasir.upm.edu.my/id/eprint/25095/7/1-s2.0-S027753870201272X-main.pdf Tarafder, M.T.H. and Khoo, Teng Jin and Crouse, Karen Anne and Ali, A.M. and Yamin, B.M. and Fun, H.K. (2002) Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). Polyhedron, 21 (27). pp. 2691-2698. ISSN 0277-5387 http://www.elsevier.com/ 10.1016/S0277-5387(02)01272-X English |
| spellingShingle | Tarafder, M.T.H. Khoo, Teng Jin Crouse, Karen Anne Ali, A.M. Yamin, B.M. Fun, H.K. Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). |
| title | Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). |
| title_full | Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). |
| title_fullStr | Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). |
| title_full_unstemmed | Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). |
| title_short | Coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate NS schiff bases derived from S-benzyldithiocarbazate and the x-ray crystal structures of S-benzyl-β-N-(5-methyl-2-furylmethylene)dithiocarbazate and bis[S-benzyl-β-N-(2-furylmethylketone)dithiocarbazato]cadmium(II). |
| title_sort | coordination chemistry and bioactivity of some metal complexes containing two isomeric bidentate ns schiff bases derived from s-benzyldithiocarbazate and the x-ray crystal structures of s-benzyl-β-n-(5-methyl-2-furylmethylene)dithiocarbazate and bis[s-benzyl-β-n-(2-furylmethylketone)dithiocarbazato]cadmium(ii). |
| url | http://psasir.upm.edu.my/id/eprint/25095/ http://psasir.upm.edu.my/id/eprint/25095/ http://psasir.upm.edu.my/id/eprint/25095/ http://psasir.upm.edu.my/id/eprint/25095/1/Coordination%20chemistry%20and%20bioactivity%20of%20some%20metal%20complexes%20containing%20two%20isomeric%20bidentate%20NS%20schiff%20bases%20derived%20from%20S.pdf http://psasir.upm.edu.my/id/eprint/25095/7/1-s2.0-S027753870201272X-main.pdf |