The growth suppressing effects of Girinimbine on Hepg2 involve induction of apoptosis and cell cycle arrest.

QR Code

The growth suppressing effects of Girinimbine on Hepg2 involve induction of apoptosis and cell cycle arrest.

Murraya koenigii is an edible herb widely used in folk medicine. Here we report that girinimbine, a carbazole alkaloid isolated from this plant, inhibited the growth and induced apoptosis in human hepatocellular carcinoma, HepG2 cells. The MTT and LDH assay results showed that girinimbine decreased...

Full description

Bibliographic Details
Main Authors:	Syam, Suvitha, Abdul, Ahmad Bustamam, Md.Sukari, Mohd. Aspollah, Mohan, Syam, Abdelwahab, Siddig Ibrahim, Tang , Sook Wah
Format:	Article
Language:	English
Published:	MDPI 2011
Online Access:	http://psasir.upm.edu.my/id/eprint/24911/

Similar Items

Apoptosis effect of girinimbine isolated from Murraya koenigii on lung cancer cells in vitro
by: Mohan, Syam, et al.
Published: (2013)

Girinimbine for use as anti cancer agent.
by: Abdul, Ahmad Bustamam, et al.
Published: (2011)

Cytotoxic Effect of Girinimbine on HepG2 Cells
by: Mohan, Suvita Syam
Published: (2011)

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells
by: Syam, Suvitha, et al.
Published: (2014)

β-mangostin suppresses LA-7 cells proliferation in vitro and in vivo: involvement of antioxidant enzyme modulation; suppression of matrix metalloproteinase and α6β4 integrin signalling pathways
by: Mohan, Suvitha Syam, et al.
Published: (2016)

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach
by: Arbab, Ismail Adam, et al.
Published: (2013)

Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 phase cell cycle arrest.
by: Mohan, Syam, et al.
Published: (2010)

Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest
by: Ng, Kuan Beng, et al.
Published: (2013)

The methalonic extract of Boesenbergia rotunda(L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action.
by: Md.Sukari, Mohd. Aspollah, et al.
Published: (2011)

β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo
by: Syam, Suvitha, et al.
Published: (2014)

Boesenbergin A, a chalcone from Boesenbergia rotunda induces apoptosis via mitochondrial dysregulation and cytochrome c release in A549 cells in vitro : involvement of HSP70 and Bcl2/Bax signalling pathways
by: Mohd Isa, Norbaiti, et al.
Published: (2013)

In vitro ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa)
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)

Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells
by: Cai, F., et al.
Published: (2016)

In vitro ultramorphological assessment of apoptosis on CEMss induce by linoleic acid-rich fraction form Typhonium flagelliforme tuber.
by: Mohan, Syam Murali, et al.
Published: (2010)

Extracts of Typhonium flagelliforme tubers for treatment of leukemia.
by: Abdul, Ahmad Bustamam, et al.
Published: (2010)

Pyranocycloartobiloxanthone a suppressed metastasis ovarian cancer cells via s phase cell cycle arrest and apoptosis
by: Mashitoh Abd Rahman,, et al.
Published: (2023)

Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss
by: Mohan, Syam, et al.
Published: (2008)

Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo
by: Mohan, Syam, et al.
Published: (2010)

Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii S.
by: Kok, Yih Yih, et al.
Published: (2012)

Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
by: Abdul Samad, Nozlena, et al.
Published: (2014)

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway
by: Waziri, Peter M., et al.
Published: (2016)

Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine
by: Nor, Siti Mariam Mohd, et al.
Published: (2017)

Induction of apoptosis by gluconasturtiin-isothiocyanate (GNST-ITC) in human hepatocarcinoma HepG2 cells and human breast adenocarcinoma MCF-7 cells
by: Arumugam, Asvinidevi, et al.
Published: (2020)

Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest
by: Armania, Nurdin, et al.
Published: (2013)

Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2007)

Zerumbone : A Natural Compound with Anti-Cholinesterase Activity.
by: Abdul, Ahmad Bustamam, et al.
Published: (2008)

Suppression effect of eurycomanone on the growth of HepG2 tumour transplanted in mice
by: Zakaria, Yusmazura
Published: (2011)

Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line
by: Moghaddam, Amin Boroumand, et al.
Published: (2017)

Synthesis of girinimbine and its derivatives and their anti- lung cancer activity
by: Osman, Fatin Nurul Atiqah
Published: (2017)

Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell
by: Etti, Imaobong Christopher, et al.
Published: (2017)

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway
by: Abang Ishak, Dayang Hazwani, et al.
Published: (2014)

In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot)
by: Mohd Isa, Noorain, et al.
Published: (2012)

Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
by: Zakaria, Yusmazura, et al.
Published: (2009)

Synthesis of an Anthraquinone Derivative (DHAQC) and its Effect on Induction of G2/M Arrest and Apoptosis in Breast Cancer MCF-7 Cell Line
by: Swee, Keong Yeap, et al.
Published: (2015)

Dicranopteris linearis extract inhibits the proliferation of human breast cancer cell line (MDA-MB-231) via induction of S-phase arrest and apoptosis
by: Baharuddin, Aifaa Akmal, et al.
Published: (2018)

Synthesis of anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell lines
by: Yeap, Swee Keong, et al.
Published: (2015)

Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)₂ towards oestrogen-receptor positive MCF-7 breast cancer cells
by: Jhi, Biau Foo, et al.
Published: (2019)

Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
by: Alshwyeh, Hussah Abdullah, et al.
Published: (2024)

A phenylbutenoid dimer, cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-3′′′,4′′′-dimethoxystyryl] cyclohex-1-ene, exhibits apoptogenic properties in T-acute lymphoblastic leukemia cells via induction of p53-independent mitochondrial signalling pathway
by: Anasamy, Theebaa, et al.
Published: (2013)

Oncolysis of breast, liver and leukemia cancer cells using ethyl acetate and methanol extracts of goniothalamus umbrosus.
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)