New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa.
Villocarines A–D (1–4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations. Villocarine A (1) showed vasorelaxation activity against rat aortic ring and showed inhibition effect...
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| Format: | Article |
| Language: | English English |
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Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24848/ http://psasir.upm.edu.my/id/eprint/24848/1/New%20vasorelaxant%20indole%20alkaloids.pdf |
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| author | Matsuo, Hirotaka Okamoto, Ryuichi Zaima, Kazumasa Hirasawa, Yusuke Ismail, Intan Safinar Lajis, Md. Nordin Morita, Hiroshi |
| author_facet | Matsuo, Hirotaka Okamoto, Ryuichi Zaima, Kazumasa Hirasawa, Yusuke Ismail, Intan Safinar Lajis, Md. Nordin Morita, Hiroshi |
| author_sort | Matsuo, Hirotaka |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Villocarines A–D (1–4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations. Villocarine A (1) showed vasorelaxation activity against rat aortic ring and showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, and also inhibition effect on phenylephrine (PE)-induced contraction in the presence of nicardipine in a Ca2+ concentration-dependent manner. The vasorelaxant effect by 1 might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels (VDC) and/or receptor-operated Ca2+-channels (ROC), and also partly mediated through the increased release of NO from endothelial cells and opening of voltage-gated K+-channels. |
| first_indexed | 2025-11-15T08:42:12Z |
| format | Article |
| id | upm-24848 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:42:12Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-248482015-10-16T06:58:32Z http://psasir.upm.edu.my/id/eprint/24848/ New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Matsuo, Hirotaka Okamoto, Ryuichi Zaima, Kazumasa Hirasawa, Yusuke Ismail, Intan Safinar Lajis, Md. Nordin Morita, Hiroshi Villocarines A–D (1–4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations. Villocarine A (1) showed vasorelaxation activity against rat aortic ring and showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, and also inhibition effect on phenylephrine (PE)-induced contraction in the presence of nicardipine in a Ca2+ concentration-dependent manner. The vasorelaxant effect by 1 might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels (VDC) and/or receptor-operated Ca2+-channels (ROC), and also partly mediated through the increased release of NO from endothelial cells and opening of voltage-gated K+-channels. Elsevier 2011-07-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24848/1/New%20vasorelaxant%20indole%20alkaloids.pdf Matsuo, Hirotaka and Okamoto, Ryuichi and Zaima, Kazumasa and Hirasawa, Yusuke and Ismail, Intan Safinar and Lajis, Md. Nordin and Morita, Hiroshi (2011) New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. Bioorganic & Medicinal Chemistry, 19 (13). pp. 4075-4079. ISSN 0968-0896; ESSN:1464-3391 http://www.elsevier.com/ 10.1016/j.bmc.2011.05.014 English |
| spellingShingle | Matsuo, Hirotaka Okamoto, Ryuichi Zaima, Kazumasa Hirasawa, Yusuke Ismail, Intan Safinar Lajis, Md. Nordin Morita, Hiroshi New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. |
| title | New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. |
| title_full | New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. |
| title_fullStr | New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. |
| title_full_unstemmed | New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. |
| title_short | New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa. |
| title_sort | new vasorelaxant indole alkaloids, villocarines a-d from uncaria villosa. |
| url | http://psasir.upm.edu.my/id/eprint/24848/ http://psasir.upm.edu.my/id/eprint/24848/ http://psasir.upm.edu.my/id/eprint/24848/ http://psasir.upm.edu.my/id/eprint/24848/1/New%20vasorelaxant%20indole%20alkaloids.pdf |