In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate
This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academic Journals
2011
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/24744/ http://psasir.upm.edu.my/id/eprint/24744/1/24744.pdf |
| _version_ | 1848845120018841600 |
|---|---|
| author | Che Seman, Che Nor Zarida Othman, Fauziah Abdul Kadir, Arifah Ahmad, Azfar Rizal Yazid, Mohd Nazri Zulkifly, Ahmad Hafiz Mustaffa, Rusnah Goriman Khan, Mohd Azam Khan Saidi, Hasni Idayu |
| author_facet | Che Seman, Che Nor Zarida Othman, Fauziah Abdul Kadir, Arifah Ahmad, Azfar Rizal Yazid, Mohd Nazri Zulkifly, Ahmad Hafiz Mustaffa, Rusnah Goriman Khan, Mohd Azam Khan Saidi, Hasni Idayu |
| author_sort | Che Seman, Che Nor Zarida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the treatment of osteomyelitis. Tobramycin and gentamicin concentrations were determined spectrophotometrically by measuring the absorbance at 400 nm. The standard graphs for tobramycin and gentamicin concentration versus absorbance reading were prepared as references to identify the concentration of the drugs release after incorporating calcium phosphate over 8 weeks. This study showed that incorporating tobramycin and gentamicin with calcium phosphate provided slow residual release of antibiotic from 30 min to 1344 h (8 weeks) and dissolution of calcium phosphate. In this respect, the drug delivery systems of tobramycin and gentamicin-incorporated calcium phosphate have potential of controlling drug release. |
| first_indexed | 2025-11-15T08:41:45Z |
| format | Article |
| id | upm-24744 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:41:45Z |
| publishDate | 2011 |
| publisher | Academic Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-247442016-04-22T06:58:46Z http://psasir.upm.edu.my/id/eprint/24744/ In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate Che Seman, Che Nor Zarida Othman, Fauziah Abdul Kadir, Arifah Ahmad, Azfar Rizal Yazid, Mohd Nazri Zulkifly, Ahmad Hafiz Mustaffa, Rusnah Goriman Khan, Mohd Azam Khan Saidi, Hasni Idayu This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the treatment of osteomyelitis. Tobramycin and gentamicin concentrations were determined spectrophotometrically by measuring the absorbance at 400 nm. The standard graphs for tobramycin and gentamicin concentration versus absorbance reading were prepared as references to identify the concentration of the drugs release after incorporating calcium phosphate over 8 weeks. This study showed that incorporating tobramycin and gentamicin with calcium phosphate provided slow residual release of antibiotic from 30 min to 1344 h (8 weeks) and dissolution of calcium phosphate. In this respect, the drug delivery systems of tobramycin and gentamicin-incorporated calcium phosphate have potential of controlling drug release. Academic Journals 2011-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24744/1/24744.pdf Che Seman, Che Nor Zarida and Othman, Fauziah and Abdul Kadir, Arifah and Ahmad, Azfar Rizal and Yazid, Mohd Nazri and Zulkifly, Ahmad Hafiz and Mustaffa, Rusnah and Goriman Khan, Mohd Azam Khan and Saidi, Hasni Idayu (2011) In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate. African Journal of Pharmacy and Pharmacology, 5 (20). art. no. 9490DED32053. pp. 2283-2291. ISSN 1996-0816 http://www.academicjournals.org/journal/AJPP/article-abstract/9490DED32053 10.5897/AJPP11.591 |
| spellingShingle | Che Seman, Che Nor Zarida Othman, Fauziah Abdul Kadir, Arifah Ahmad, Azfar Rizal Yazid, Mohd Nazri Zulkifly, Ahmad Hafiz Mustaffa, Rusnah Goriman Khan, Mohd Azam Khan Saidi, Hasni Idayu In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| title | In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| title_full | In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| title_fullStr | In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| title_full_unstemmed | In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| title_short | In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| title_sort | in vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate |
| url | http://psasir.upm.edu.my/id/eprint/24744/ http://psasir.upm.edu.my/id/eprint/24744/ http://psasir.upm.edu.my/id/eprint/24744/ http://psasir.upm.edu.my/id/eprint/24744/1/24744.pdf |