Three new amides from Streptomyces sp. H7372
Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24724/ http://psasir.upm.edu.my/id/eprint/24724/1/Three%20new%20amides%20from%20streptomyces%20sp.pdf |
| _version_ | 1848845114578829312 |
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| author | Cheenpracha, Sarot Borris, Robert P. Tran, Tammy T. Jee, Jap Meng Seow, Heng Fong Cheah, Hwen Yee Ho, Coy Choke Chang, Leng Chee |
| author_facet | Cheenpracha, Sarot Borris, Robert P. Tran, Tammy T. Jee, Jap Meng Seow, Heng Fong Cheah, Hwen Yee Ho, Coy Choke Chang, Leng Chee |
| author_sort | Cheenpracha, Sarot |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(δAla-L- Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two- hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His - and inactive on SD His + at 2.5 μg per disk, respectively. |
| first_indexed | 2025-11-15T08:41:40Z |
| format | Article |
| id | upm-24724 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:41:40Z |
| publishDate | 2011 |
| publisher | Sociedade Brasileira de Química |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-247242016-12-02T03:33:34Z http://psasir.upm.edu.my/id/eprint/24724/ Three new amides from Streptomyces sp. H7372 Cheenpracha, Sarot Borris, Robert P. Tran, Tammy T. Jee, Jap Meng Seow, Heng Fong Cheah, Hwen Yee Ho, Coy Choke Chang, Leng Chee Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-β-D- glucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(δAla-L- Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast two- hybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His - and inactive on SD His + at 2.5 μg per disk, respectively. Sociedade Brasileira de Química 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24724/1/Three%20new%20amides%20from%20streptomyces%20sp.pdf Cheenpracha, Sarot and Borris, Robert P. and Tran, Tammy T. and Jee, Jap Meng and Seow, Heng Fong and Cheah, Hwen Yee and Ho, Coy Choke and Chang, Leng Chee (2011) Three new amides from Streptomyces sp. H7372. Journal of the Brazilian Chemical Society, 22 (2). pp. 223-229. ISSN 0103-5053; ESSN: 1678-4790 10.1590/S0103-50532011000200006 |
| spellingShingle | Cheenpracha, Sarot Borris, Robert P. Tran, Tammy T. Jee, Jap Meng Seow, Heng Fong Cheah, Hwen Yee Ho, Coy Choke Chang, Leng Chee Three new amides from Streptomyces sp. H7372 |
| title | Three new amides from Streptomyces sp. H7372 |
| title_full | Three new amides from Streptomyces sp. H7372 |
| title_fullStr | Three new amides from Streptomyces sp. H7372 |
| title_full_unstemmed | Three new amides from Streptomyces sp. H7372 |
| title_short | Three new amides from Streptomyces sp. H7372 |
| title_sort | three new amides from streptomyces sp. h7372 |
| url | http://psasir.upm.edu.my/id/eprint/24724/ http://psasir.upm.edu.my/id/eprint/24724/ http://psasir.upm.edu.my/id/eprint/24724/1/Three%20new%20amides%20from%20streptomyces%20sp.pdf |