Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
Thymoquinone (TQ), the active constituent of Nigella sativa or black cumin exhibited cytotoxic effects in several cancer cell lines. In this study, the cytotoxicity of TQ in human cervical squamous carcinoma cells (SiHa) was investigated. TQ was cytotoxic towards SiHa cells with IC50 values of 10.67...
| Main Authors: | Ng, Wei Keat, Saiful Yazan, Latifah, Ismail, Maznah |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/24708/ http://psasir.upm.edu.my/id/eprint/24708/1/Thmoquinone%20from%20Nigella%20sativa%20was%20more%20potent%20than%20cisplatin%20in%20eliminating%20of%20SiHa%20cells%20via%20apoptosis%20with%20down.pdf |
Similar Items
Cytotoxicity of thymoquinone and thymoquinone-loaded nanostrustured lipid carrier on cervical cancer cells (SiHa and HeLa)
by: Ng, Wei Keat
Published: (2015)
by: Ng, Wei Keat
Published: (2015)
Semi-purified fraction of Clinacanthus nutans induced apoptosis in human cervical cancer, SiHa cells via up-regulation of bax and down-regulation of Bcl-2
by: Nik Aina Syazana Nik Zainuddin,, et al.
Published: (2019)
by: Nik Aina Syazana Nik Zainuddin,, et al.
Published: (2019)
Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa)
by: Wei, Keat Ng, et al.
Published: (2015)
by: Wei, Keat Ng, et al.
Published: (2015)
Cytotoxicity of Thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa).
by: Saiful Yazan, Latifah, et al.
Published: (2009)
by: Saiful Yazan, Latifah, et al.
Published: (2009)
Extraction of pharmacologically active thymoquinone in nigella sativa L.
by: Nazeri, Nasaruddin
Published: (2006)
by: Nazeri, Nasaruddin
Published: (2006)
Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and thymoquinone-based therapy
by: Wan Abd Ghani, Wan Nor Hafiza, et al.
Published: (2014)
by: Wan Abd Ghani, Wan Nor Hafiza, et al.
Published: (2014)
Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines.
by: Ismail, Norsharina, et al.
Published: (2011)
by: Ismail, Norsharina, et al.
Published: (2011)
The chemopreventive effects of Nigella sativa extract and Thymoquinone in a paternal toxicity study
by: Abdul Samat, Nadia Hanis, et al.
Published: (2015)
by: Abdul Samat, Nadia Hanis, et al.
Published: (2015)
Extraction, Gene Regulation and Hypocholesterolemic Effects, and Antioxidative Activity of Thymoquinone Rich Fraction and Thymoquinone from Nigella Sativa (pdf incomplete)
by: Al-Naqeeb, Ghanya Naji
Published: (2009)
by: Al-Naqeeb, Ghanya Naji
Published: (2009)
The potential of nigella sativa and thymoquinone in salvaging the embryo from effects of toxic paternal exposure
by: Abdul Samat, Nadia Hanis, et al.
Published: (2016)
by: Abdul Samat, Nadia Hanis, et al.
Published: (2016)
Potential effects of Nigella sativa and thymoquinone on the foetal development of cyclophosphamide-treated male mice
by: Abdul Rahman, Suzanah, et al.
Published: (2016)
by: Abdul Rahman, Suzanah, et al.
Published: (2016)
The potential of Nigella Sativa and thymoquinone in salvaging the embryo from effects of toxic paternal exposure
by: Abdul Samat, Nadia Hanis, et al.
Published: (2016)
by: Abdul Samat, Nadia Hanis, et al.
Published: (2016)
Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
by: Mayola, E., et al.
Published: (2011)
by: Mayola, E., et al.
Published: (2011)
Evaluation of the anti-cancer potential of Nigella sativa and its bioactive constituents thymoquinone and alpha-hederin
by: Zafar, Mashal
Published: (2024)
by: Zafar, Mashal
Published: (2024)
Anti-cancer activities of Thymoquinone, constituents of Nigella sativa against oral cancer cell lines
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2010)
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2010)
Investigating the potential of Nigella Sativa and thymoquinone in salvaging the embryo from effects of toxic paternal exposure to cyclophosphamide
by: Abdul Rahman, Suzanah, et al.
Published: (2017)
by: Abdul Rahman, Suzanah, et al.
Published: (2017)
Investigating the potential of Nigella sativa and thymoquinone in salvaging the embryo from effects of toxic paternal exposure to cyclophosphamide
by: Abdul Rahman, Suzanah, et al.
Published: (2017)
by: Abdul Rahman, Suzanah, et al.
Published: (2017)
Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2014)
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2014)
Antioxidant property, thymoquinone content and chemical characteristics of different extracts from Nigella sativa L. seeds
by: Solati, Zeinab, et al.
Published: (2014)
by: Solati, Zeinab, et al.
Published: (2014)
Thymoquinone, an active ingredient of Black Seed (Nigela saliva) induces distinct apoptotic pathways in C33A and Siha Cervical Cancer Cell Lines)
by: Ichwan, Solachuddin JA, et al.
Published: (2012)
by: Ichwan, Solachuddin JA, et al.
Published: (2012)
Desferrithiocin is a more potent antineoplastic agent than desferrioxamine
by: Kicic, Anthony, et al.
Published: (2002)
by: Kicic, Anthony, et al.
Published: (2002)
Prophylactic effects of Nigella sativa extract and thymoquinone against cyclophosphamide-induced sperm head abnormalities and chromatin instability in mice
by: Abdul Rahman, Suzanah, et al.
Published: (2017)
by: Abdul Rahman, Suzanah, et al.
Published: (2017)
Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
by: Shanmugam, M., et al.
Published: (2018)
by: Shanmugam, M., et al.
Published: (2018)
Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
by: Shanmugam, M., et al.
Published: (2017)
by: Shanmugam, M., et al.
Published: (2017)
Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats.
by: Ismail , Maznah, et al.
Published: (2010)
by: Ismail , Maznah, et al.
Published: (2010)
Nordamnacanthal induced apoptosis and mitotic-G2/M arrest with downregulation of Bcl-2 in the human breast cancer cell line (MCF-7).
by: Ishak , Norsyafini, et al.
Published: (2010)
by: Ishak , Norsyafini, et al.
Published: (2010)
Thymoquinone loaded nanostructured lipid carriers (TQ-NLC) and uses thereof
by: Saiful Yazan, Latifah, et al.
Published: (2012)
by: Saiful Yazan, Latifah, et al.
Published: (2012)
Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the txJ Mouse is a Better Model of Hepatic than Brain Cu Toxicity
by: Chan, H., et al.
Published: (2008)
by: Chan, H., et al.
Published: (2008)
Mechanisms of cisplatin-induced cell death in malignant mesothelioma cells: Role of inhibitor of apoptosis proteins (IAPs) and caspases
by: Cregan, I., et al.
Published: (2013)
by: Cregan, I., et al.
Published: (2013)
Determination of the role of miR-210 AND miR-629 in regulating response towards 1'S-1'-acetoxychavicol acetate in human cervical carcinoma cells CaSki AND SiHa / Phuah Neoh Hun
by: Phuah, Neoh Hun
Published: (2017)
by: Phuah, Neoh Hun
Published: (2017)
Increase of Bcl-2/Bax ratio corelated with decrease of
lymphocyte apoptosis: a study in the bronchiolus and
lung of asthmatic mice
by: Hasan, Taufiq Hidayat, et al.
Published: (2013)
by: Hasan, Taufiq Hidayat, et al.
Published: (2013)
Increased of Bcl-2/Bax ratio corelated with decreased of lymphocyte apoptosis: a study in the bronchiolus and lung of asthmatic mice
by: Hasan, Taufiq Hidayat, et al.
Published: (2013)
by: Hasan, Taufiq Hidayat, et al.
Published: (2013)
Cockle shell-derived aragonite CaCO3 nanoparticles for co-delivery of doxorubicin and thymoquinone eliminates cancer stem cells
by: Ibiyeye, Kehinde Muibat, et al.
Published: (2020)
by: Ibiyeye, Kehinde Muibat, et al.
Published: (2020)
Evaluating the immunopathological effects of nigella sativa oil and its major component, thymoquinone in a streptozotocin-induces type1 diabetes rat model / Afaf Jamal Ali Hmza
by: Ali Hmza, Afaf Jamal
Published: (2013)
by: Ali Hmza, Afaf Jamal
Published: (2013)
Preparation and characterization of nigella sativa microemulsions
by: Mohd Nor, Nurul Hafizah, et al.
Published: (2014)
by: Mohd Nor, Nurul Hafizah, et al.
Published: (2014)
Migration and proliferation effects of Thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) and Thymoquinone (TQ) on in vitro wound healing models
by: Alexander, Henna Roshini, et al.
Published: (2019)
by: Alexander, Henna Roshini, et al.
Published: (2019)
Physicochemical characteristics of Nigella seed (Nigella sativa L.) oil as affected by different extraction methods.
by: Khoddami, Ali, et al.
Published: (2011)
by: Khoddami, Ali, et al.
Published: (2011)
Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression.
by: Al-Naqeep, Ghanya, et al.
Published: (2009)
by: Al-Naqeep, Ghanya, et al.
Published: (2009)
Regulation of p53-, Bcl-2- and Caspase-dependent Signaling Pathway in Xanthorrhizol-induced Apoptosis of HepG2 Hepatoma Cells
by: Tri Handayani,, et al.
Published: (2007)
by: Tri Handayani,, et al.
Published: (2007)
Potential surface active properties of Nigella sativa
by: Said, Siti Nurfajariah, et al.
Published: (2011)
by: Said, Siti Nurfajariah, et al.
Published: (2011)
Similar Items
-
Cytotoxicity of thymoquinone and thymoquinone-loaded nanostrustured lipid carrier on cervical cancer cells (SiHa and HeLa)
by: Ng, Wei Keat
Published: (2015) -
Semi-purified fraction of Clinacanthus nutans induced apoptosis in human cervical cancer, SiHa cells via up-regulation of bax and down-regulation of Bcl-2
by: Nik Aina Syazana Nik Zainuddin,, et al.
Published: (2019) -
Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa)
by: Wei, Keat Ng, et al.
Published: (2015) -
Cytotoxicity of Thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa).
by: Saiful Yazan, Latifah, et al.
Published: (2009) -
Extraction of pharmacologically active thymoquinone in nigella sativa L.
by: Nazeri, Nasaruddin
Published: (2006)