Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure?
The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
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Institute for Medical Research and Occupational Health, Zagreb
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24706/ http://psasir.upm.edu.my/id/eprint/24706/1/Does%20GSTP1%20polymorphism%20contribute%20to%20genetic%20damage%20caused%20by%20ageing%20and%20occupational%20exposure.pdf |
| _version_ | 1848845109571878912 |
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| author | Eshkoor, Sima Ataollahi Ismail , Patimah Abdul Rahman, Sabariah Moin, Saidi |
| author_facet | Eshkoor, Sima Ataollahi Ismail , Patimah Abdul Rahman, Sabariah Moin, Saidi |
| author_sort | Eshkoor, Sima Ataollahi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells collected from occupationally exposed and non-exposed (control) subjects. Samples were analysed using cytogenetic and molecular methods, including restriction fragment length polymorphism (RFLP), MN test, comet assay, and real-time PCR. The results confirmed the DNA damaging effects of substances used in the mechanical workshops, but did not confirm the influence of GSTP1 gene polymorphism on DNA damage. However, further studies on both occupationally exposed and control populations are needed to understand the relationship between GSTP1 polymorphism and genome damage. |
| first_indexed | 2025-11-15T08:41:35Z |
| format | Article |
| id | upm-24706 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:41:35Z |
| publishDate | 2011 |
| publisher | Institute for Medical Research and Occupational Health, Zagreb |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-247062015-09-09T06:55:13Z http://psasir.upm.edu.my/id/eprint/24706/ Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? Eshkoor, Sima Ataollahi Ismail , Patimah Abdul Rahman, Sabariah Moin, Saidi The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells collected from occupationally exposed and non-exposed (control) subjects. Samples were analysed using cytogenetic and molecular methods, including restriction fragment length polymorphism (RFLP), MN test, comet assay, and real-time PCR. The results confirmed the DNA damaging effects of substances used in the mechanical workshops, but did not confirm the influence of GSTP1 gene polymorphism on DNA damage. However, further studies on both occupationally exposed and control populations are needed to understand the relationship between GSTP1 polymorphism and genome damage. Institute for Medical Research and Occupational Health, Zagreb 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24706/1/Does%20GSTP1%20polymorphism%20contribute%20to%20genetic%20damage%20caused%20by%20ageing%20and%20occupational%20exposure.pdf Eshkoor, Sima Ataollahi and Ismail , Patimah and Abdul Rahman, Sabariah and Moin, Saidi (2011) Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? Arhiv za Higijenu Rada i Toksikologiju , 62 (4). pp. 291-298. ISSN 0004-1254 http://www.imi.hr/ 10.2478/10004-1254-62-2011-2088 English |
| spellingShingle | Eshkoor, Sima Ataollahi Ismail , Patimah Abdul Rahman, Sabariah Moin, Saidi Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| title | Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| title_full | Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| title_fullStr | Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| title_full_unstemmed | Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| title_short | Does GSTP1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| title_sort | does gstp1 polymorphism contribute to genetic damage caused by ageing and occupational exposure? |
| url | http://psasir.upm.edu.my/id/eprint/24706/ http://psasir.upm.edu.my/id/eprint/24706/ http://psasir.upm.edu.my/id/eprint/24706/ http://psasir.upm.edu.my/id/eprint/24706/1/Does%20GSTP1%20polymorphism%20contribute%20to%20genetic%20damage%20caused%20by%20ageing%20and%20occupational%20exposure.pdf |