In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves.
The present study aims to determine the in vitro antiproliferative and antioxidant activities of various extracts from the leaves of Melastoma malabathricum using various established in vitro assays. The aqueous extract inhibited the proliferation of Caov-3 and HL-60 cell lines, while the chloroform...
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Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24678/ http://psasir.upm.edu.my/id/eprint/24678/1/In%20vitro%20antiproliferative%20and%20antioxidant%20activities.pdf |
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| author | Zakaria, Zainul Amiruddin Rofiee, M.S. Mohamed, A.M. Teh , L.K. Salleh, M.Z. |
| author_facet | Zakaria, Zainul Amiruddin Rofiee, M.S. Mohamed, A.M. Teh , L.K. Salleh, M.Z. |
| author_sort | Zakaria, Zainul Amiruddin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present study aims to determine the in vitro antiproliferative and antioxidant activities of various extracts from the leaves of Melastoma malabathricum using various established in vitro assays. The aqueous extract inhibited the proliferation of Caov-3 and HL-60 cell lines, while the chloroform extract exhibited antiproliferative activity against the Caov-3, HL-60, and CEM-SS cell lines. The methanol extract demonstrated antiproliferative activity against more cell lines, including the MCF-7, HeLa, Caov-3, HL-60, CEM-SS, and MDA-MB-231 cancer cell lines. Interestingly, all extracts did not inhibit the proliferation of 3T3 cells, thus indicating their noncytotoxic properties. Unlike the chloroform extracts, the aqueous and methanol extracts of M malabathricum (20, 100, and 500. μg/ml) produced high antioxidant activity for the superoxide scavenging assay with only the 500. μg/ml aqueous and methanol extracts exhibited high activity for the 2,2-diphenyl -1-picrylhydrazyl radical scavenging assay. The total phenolic content recorded for the aqueous, methanol, and chloroform extracts were 3344.2 ± 19.1, 3055.1 ± 8.7, and 92.5 ± 7.3. mg/100. g of gallic acid, respectively. The M malabathricum leaves possessed potential antiproliferative and antioxidant activities that could be attributed to its high content of phenolic compounds. |
| first_indexed | 2025-11-15T08:41:28Z |
| format | Article |
| id | upm-24678 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:41:28Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-246782015-11-18T03:00:07Z http://psasir.upm.edu.my/id/eprint/24678/ In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. Zakaria, Zainul Amiruddin Rofiee, M.S. Mohamed, A.M. Teh , L.K. Salleh, M.Z. The present study aims to determine the in vitro antiproliferative and antioxidant activities of various extracts from the leaves of Melastoma malabathricum using various established in vitro assays. The aqueous extract inhibited the proliferation of Caov-3 and HL-60 cell lines, while the chloroform extract exhibited antiproliferative activity against the Caov-3, HL-60, and CEM-SS cell lines. The methanol extract demonstrated antiproliferative activity against more cell lines, including the MCF-7, HeLa, Caov-3, HL-60, CEM-SS, and MDA-MB-231 cancer cell lines. Interestingly, all extracts did not inhibit the proliferation of 3T3 cells, thus indicating their noncytotoxic properties. Unlike the chloroform extracts, the aqueous and methanol extracts of M malabathricum (20, 100, and 500. μg/ml) produced high antioxidant activity for the superoxide scavenging assay with only the 500. μg/ml aqueous and methanol extracts exhibited high activity for the 2,2-diphenyl -1-picrylhydrazyl radical scavenging assay. The total phenolic content recorded for the aqueous, methanol, and chloroform extracts were 3344.2 ± 19.1, 3055.1 ± 8.7, and 92.5 ± 7.3. mg/100. g of gallic acid, respectively. The M malabathricum leaves possessed potential antiproliferative and antioxidant activities that could be attributed to its high content of phenolic compounds. Elsevier 2011-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24678/1/In%20vitro%20antiproliferative%20and%20antioxidant%20activities.pdf Zakaria, Zainul Amiruddin and Rofiee, M.S. and Mohamed, A.M. and Teh , L.K. and Salleh, M.Z. (2011) In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. Journal of Acupuncture and Meridian Studies, 4 (4). pp. 248-256. ISSN 2005-2901; ESSN:2093-8152 http://www.elsevier.com/ 10.1016/j.jams.2011.09.016 English |
| spellingShingle | Zakaria, Zainul Amiruddin Rofiee, M.S. Mohamed, A.M. Teh , L.K. Salleh, M.Z. In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| title | In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| title_full | In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| title_fullStr | In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| title_full_unstemmed | In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| title_short | In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| title_sort | in vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of melastoma malabathricum leaves. |
| url | http://psasir.upm.edu.my/id/eprint/24678/ http://psasir.upm.edu.my/id/eprint/24678/ http://psasir.upm.edu.my/id/eprint/24678/ http://psasir.upm.edu.my/id/eprint/24678/1/In%20vitro%20antiproliferative%20and%20antioxidant%20activities.pdf |