Evaluating of high fructose diet to induce hyperglycemia and its inflammatory complication in rats.
It has been reported that a diet enriched in fructose would present animal models used to emulate diabetes mellitus type 2 in human. This study aimed to examine the effect of high fructose induction on the blood glucose, C-reactive protein, interleukin-6, interleukin-4 and body weight among high fru...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Asian Network for Scientific Information
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24647/ http://psasir.upm.edu.my/id/eprint/24647/1/Evaluating%20of%20high%20fructose%20diet%20to%20induce%20hyperglycemia%20and%20its%20inflammatory%20complication%20in%20rats.pdf |
| Summary: | It has been reported that a diet enriched in fructose would present animal models used to emulate diabetes mellitus type 2 in human. This study aimed to examine the effect of high fructose induction on the blood glucose, C-reactive protein, interleukin-6, interleukin-4 and body weight among high fructose diet-induced rats. The HFD was induced through drinking water in 21% (w/v) concentration among male Sprague-Dawley rats. The high fructose diet administration was unable to induce hyperglycemia, hypertriglyceridemia or any classic inflammatory markers. Also, no histological inflammation was observed. It was concluded that healthy Sprague-Dawley rats fed high fructose diet for 2.5 months could not develop signs of diabetes mellitus type 2. |
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