Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and â-catenin and enhances invasion in nasopharyngeal carcinoma cells.

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Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and â-catenin and enhances invasion in nasopharyngeal carcinoma cells.

Dysregulation of E-cadherin and β-catenin function in cell-cell adhesion is common in nasopharyngeal carcinoma (NPC) and correlates with metastatic disease. In this study, we examined the role of EGF-activated phosphatidylinositol 3-kinase (PI3K)-Akt signaling in E-cadherin and β-catenin regulation....

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Bibliographic Details
Main Authors:	Wai, Kien Yip, Seow, Heng Fong
Format:	Article
Language:	English English
Published:	Elsevier 2012
Online Access:	http://psasir.upm.edu.my/id/eprint/24623/ http://psasir.upm.edu.my/id/eprint/24623/1/Activation%20of%20phosphatidylinositol%203.pdf

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