Inhibitory effects of palm a-, c- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia.
Anti-inflammatory actions of the vitamin E fragment tocotrienol have not been described for microglia. Here, we screened palm α-, γ- and δ-tocotrienol isoforms and Tocomin® 50% (contains spectrum of tocotrienols and tocopherols) for their ability to limit nitric oxide (NO) production by BV2 microgli...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24566/ http://psasir.upm.edu.my/id/eprint/24566/1/Inhibitory%20effects%20of%20palm%20a.pdf |
| _version_ | 1848845071390081024 |
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| author | Tan, Shi Wei Ramasamy, Rajesh Abdullah, Maha Vidyadaran, Sharmili |
| author_facet | Tan, Shi Wei Ramasamy, Rajesh Abdullah, Maha Vidyadaran, Sharmili |
| author_sort | Tan, Shi Wei |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Anti-inflammatory actions of the vitamin E fragment tocotrienol have not been described for microglia. Here, we screened palm α-, γ- and δ-tocotrienol isoforms and Tocomin® 50% (contains spectrum of tocotrienols and tocopherols) for their ability to limit nitric oxide (NO) production by BV2 microglia. Microglia were treated with varying doses of tocotrienols for 24h and stimulated with 1 μg/ml lipopolysaccharide (LPS). All tocotrienol isoforms reduced NO release by LPS-stimulated microglia, with 50 μM being the most potent tocotrienol dose. Of the isoforms tested, δ-tocotrienol lowered NO levels the most, reducing NO by approximately 50% at 48 h post-LPS treatment (p<.05). None of the tocotrienol doses tested affected microglia viability. |
| first_indexed | 2025-11-15T08:40:59Z |
| format | Article |
| id | upm-24566 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:40:59Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245662016-01-12T04:32:32Z http://psasir.upm.edu.my/id/eprint/24566/ Inhibitory effects of palm a-, c- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Tan, Shi Wei Ramasamy, Rajesh Abdullah, Maha Vidyadaran, Sharmili Anti-inflammatory actions of the vitamin E fragment tocotrienol have not been described for microglia. Here, we screened palm α-, γ- and δ-tocotrienol isoforms and Tocomin® 50% (contains spectrum of tocotrienols and tocopherols) for their ability to limit nitric oxide (NO) production by BV2 microglia. Microglia were treated with varying doses of tocotrienols for 24h and stimulated with 1 μg/ml lipopolysaccharide (LPS). All tocotrienol isoforms reduced NO release by LPS-stimulated microglia, with 50 μM being the most potent tocotrienol dose. Of the isoforms tested, δ-tocotrienol lowered NO levels the most, reducing NO by approximately 50% at 48 h post-LPS treatment (p<.05). None of the tocotrienol doses tested affected microglia viability. Elsevier 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24566/1/Inhibitory%20effects%20of%20palm%20a.pdf Tan, Shi Wei and Ramasamy, Rajesh and Abdullah, Maha and Vidyadaran, Sharmili (2011) Inhibitory effects of palm a-, c- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Cellular Immunology, 271 (2011). pp. 205-209. ISSN 0008-8749; ESSN: 1090-2163 10.1016/j.cellimm.2011.07.012 English |
| spellingShingle | Tan, Shi Wei Ramasamy, Rajesh Abdullah, Maha Vidyadaran, Sharmili Inhibitory effects of palm a-, c- and δ-tocotrienol on lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| title | Inhibitory effects of palm a-, c- and δ-tocotrienol on
lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| title_full | Inhibitory effects of palm a-, c- and δ-tocotrienol on
lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| title_fullStr | Inhibitory effects of palm a-, c- and δ-tocotrienol on
lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| title_full_unstemmed | Inhibitory effects of palm a-, c- and δ-tocotrienol on
lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| title_short | Inhibitory effects of palm a-, c- and δ-tocotrienol on
lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| title_sort | inhibitory effects of palm a-, c- and δ-tocotrienol on
lipopolysaccharide-induced nitric oxide production in bv2 microglia. |
| url | http://psasir.upm.edu.my/id/eprint/24566/ http://psasir.upm.edu.my/id/eprint/24566/ http://psasir.upm.edu.my/id/eprint/24566/1/Inhibitory%20effects%20of%20palm%20a.pdf |