Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-i...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2011
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/24546/ http://psasir.upm.edu.my/id/eprint/24546/1/Preliminary%20analysis%20of%20the%20anti.pdf |
| _version_ | 1848845065941680128 |
|---|---|
| author | Zakaria, Zainul Amiruddin Tengku Mohamad, Tengku Azam Shah Ahmad, M. S. Mokhtar, A. F. Israf Ali, Daud Ahmad Lajis, Nordin Sulaiman, Mohd Roslan |
| author_facet | Zakaria, Zainul Amiruddin Tengku Mohamad, Tengku Azam Shah Ahmad, M. S. Mokhtar, A. F. Israf Ali, Daud Ahmad Lajis, Nordin Sulaiman, Mohd Roslan |
| author_sort | Zakaria, Zainul Amiruddin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments. |
| first_indexed | 2025-11-15T08:40:54Z |
| format | Article |
| id | upm-24546 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:40:54Z |
| publishDate | 2011 |
| publisher | SAGE Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245462018-10-11T07:46:44Z http://psasir.upm.edu.my/id/eprint/24546/ Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet Zakaria, Zainul Amiruddin Tengku Mohamad, Tengku Azam Shah Ahmad, M. S. Mokhtar, A. F. Israf Ali, Daud Ahmad Lajis, Nordin Sulaiman, Mohd Roslan Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments. SAGE Publications 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24546/1/Preliminary%20analysis%20of%20the%20anti.pdf Zakaria, Zainul Amiruddin and Tengku Mohamad, Tengku Azam Shah and Ahmad, M. S. and Mokhtar, A. F. and Israf Ali, Daud Ahmad and Lajis, Nordin and Sulaiman, Mohd Roslan (2011) Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet. Biological Research For Nursing, 13 (4). pp. 425-432. ISSN 1099-8004; ESSN: 1552-4175 http://journals.sagepub.com/doi/abs/10.1177/1099800410386590 10.1177/1099800410386590 |
| spellingShingle | Zakaria, Zainul Amiruddin Tengku Mohamad, Tengku Azam Shah Ahmad, M. S. Mokhtar, A. F. Israf Ali, Daud Ahmad Lajis, Nordin Sulaiman, Mohd Roslan Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet |
| title | Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet |
| title_full | Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet |
| title_fullStr | Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet |
| title_full_unstemmed | Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet |
| title_short | Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet |
| title_sort | preliminary analysis of the anti-inflammatory activity of essential oils of zingiber zerumbet |
| url | http://psasir.upm.edu.my/id/eprint/24546/ http://psasir.upm.edu.my/id/eprint/24546/ http://psasir.upm.edu.my/id/eprint/24546/ http://psasir.upm.edu.my/id/eprint/24546/1/Preliminary%20analysis%20of%20the%20anti.pdf |