The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT.
INTRODUCTION: This study aimed to evaluate the diagnostic value of dual time point imaging (DTPI) of 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) for detecting the infective lesions in patients with extrapulmonary tuberculosis (EPTB). METHODS: Eleven patients were consecu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Wiley
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24537/ http://psasir.upm.edu.my/id/eprint/24537/1/The%20imaging%20characteristics%20of%20extrapulmonary%20tuberculous%20lesions%20on%20dual%20time%20point%20imaging.pdf |
| _version_ | 1848845063234256896 |
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| author | Abdul Razak, Hairil Rashmizal Geso, Moshi Abdul Rahim, Noraini Nordin, Abdul Jalil |
| author_facet | Abdul Razak, Hairil Rashmizal Geso, Moshi Abdul Rahim, Noraini Nordin, Abdul Jalil |
| author_sort | Abdul Razak, Hairil Rashmizal |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | INTRODUCTION:
This study aimed to evaluate the diagnostic value of dual time point imaging (DTPI) of 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) for detecting the infective lesions in patients with extrapulmonary tuberculosis (EPTB).
METHODS:
Eleven patients were consecutively recruited and evaluated. After the intravenous injection of 369 ± 153 MBq of FDG, all patients underwent FDG PET/CT imaging at two different time points: early scan at 57 ± 23 min and delayed scan at 136 ± 42 min. The maximum standardized uptake values (SUVmax) were recorded for both time points (early scan: SUVmax1 and delayed scan: SUVmax2).
RESULTS:
In total, 30 lesions were detected. The SUVmax2 in 22 of the lesions in confirmed EPTB patients were significantly higher than the SUVmax1 (7.9 ± 3.2 vs. 6.8 ± 2.5; P = 0.001). The SUVmax for another eight non-EPTB lesions also showed a significant increasing pattern of change (6.2 ± 2.6 vs. 6.5 ± 2.8; P = 0.044). However, there was insignificant difference between the mean percentage difference of SUVmax (%ΔSUVmax) of EPTB and non-EPTB lesions (P = 0.06).
CONCLUSION:
Our study demonstrates that early whole body PET/CT imaging may be sufficient for the detection of the EPTB lesions and DTPI of PET/CT may also not be a useful technique in differentiating between EPTB and non-EPTB lesions. However, our findings are based on a limited number of patients, and therefore, further investigations in larger series of patients are warranted. |
| first_indexed | 2025-11-15T08:40:51Z |
| format | Article |
| id | upm-24537 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:40:51Z |
| publishDate | 2011 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245372015-10-21T07:06:36Z http://psasir.upm.edu.my/id/eprint/24537/ The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. Abdul Razak, Hairil Rashmizal Geso, Moshi Abdul Rahim, Noraini Nordin, Abdul Jalil INTRODUCTION: This study aimed to evaluate the diagnostic value of dual time point imaging (DTPI) of 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) for detecting the infective lesions in patients with extrapulmonary tuberculosis (EPTB). METHODS: Eleven patients were consecutively recruited and evaluated. After the intravenous injection of 369 ± 153 MBq of FDG, all patients underwent FDG PET/CT imaging at two different time points: early scan at 57 ± 23 min and delayed scan at 136 ± 42 min. The maximum standardized uptake values (SUVmax) were recorded for both time points (early scan: SUVmax1 and delayed scan: SUVmax2). RESULTS: In total, 30 lesions were detected. The SUVmax2 in 22 of the lesions in confirmed EPTB patients were significantly higher than the SUVmax1 (7.9 ± 3.2 vs. 6.8 ± 2.5; P = 0.001). The SUVmax for another eight non-EPTB lesions also showed a significant increasing pattern of change (6.2 ± 2.6 vs. 6.5 ± 2.8; P = 0.044). However, there was insignificant difference between the mean percentage difference of SUVmax (%ΔSUVmax) of EPTB and non-EPTB lesions (P = 0.06). CONCLUSION: Our study demonstrates that early whole body PET/CT imaging may be sufficient for the detection of the EPTB lesions and DTPI of PET/CT may also not be a useful technique in differentiating between EPTB and non-EPTB lesions. However, our findings are based on a limited number of patients, and therefore, further investigations in larger series of patients are warranted. Wiley 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24537/1/The%20imaging%20characteristics%20of%20extrapulmonary%20tuberculous%20lesions%20on%20dual%20time%20point%20imaging.pdf Abdul Razak, Hairil Rashmizal and Geso, Moshi and Abdul Rahim, Noraini and Nordin, Abdul Jalil (2011) The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. Journal of Medical Imaging and Radiation Oncology, 55 (6). pp. 556-562. ISSN 1754-9477; ESSN: 1754-9485 10.1111/j.1754-9485.2011.02309.x English |
| spellingShingle | Abdul Razak, Hairil Rashmizal Geso, Moshi Abdul Rahim, Noraini Nordin, Abdul Jalil The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. |
| title | The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. |
| title_full | The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. |
| title_fullStr | The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. |
| title_full_unstemmed | The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. |
| title_short | The imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (DTPI) of FDG PET/CT. |
| title_sort | imaging characteristics of extrapulmonary tuberculous lesions on dual time point imaging (dtpi) of fdg pet/ct. |
| url | http://psasir.upm.edu.my/id/eprint/24537/ http://psasir.upm.edu.my/id/eprint/24537/ http://psasir.upm.edu.my/id/eprint/24537/1/The%20imaging%20characteristics%20of%20extrapulmonary%20tuberculous%20lesions%20on%20dual%20time%20point%20imaging.pdf |