Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements
Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein. The circulating M-protein may consist of an intact immunoglobu...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24524/ http://psasir.upm.edu.my/id/eprint/24524/1/Monoclonal%20gammopathy%20with%20systemic%20amylodosis%20an%20evaluation%20of%20diagnostic%20elements.pdf |
| _version_ | 1848845060457627648 |
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| author | Chellappah Thambiah, Subashini George, Elizabeth Umar, Nor Aini |
| author_facet | Chellappah Thambiah, Subashini George, Elizabeth Umar, Nor Aini |
| author_sort | Chellappah Thambiah, Subashini |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein. The circulating M-protein may consist of an intact immunoglobulin, the light chain only, or (rarely) the heavy chain only. The heavy chain is from one of the five immunoglobulin classes G, A, M, D or E, while the light chain is either kappa (κ) or lambda (λ) in type. Accurate detection and quantitation of monoclonal immunoglobulins is important for the diagnosis and management of monoclonal gammopathies. We report a case of a 71 year old lady with a history of chronic gastritis and recurrent lower respiratory tract infection whereby no specific diagnosis was made until a computed tomography (CT) guided lung biopsy and orogastroduodenoscopy. |
| first_indexed | 2025-11-15T08:40:49Z |
| format | Article |
| id | upm-24524 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:40:49Z |
| publishDate | 2011 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245242018-01-05T03:07:50Z http://psasir.upm.edu.my/id/eprint/24524/ Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements Chellappah Thambiah, Subashini George, Elizabeth Umar, Nor Aini Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein. The circulating M-protein may consist of an intact immunoglobulin, the light chain only, or (rarely) the heavy chain only. The heavy chain is from one of the five immunoglobulin classes G, A, M, D or E, while the light chain is either kappa (κ) or lambda (λ) in type. Accurate detection and quantitation of monoclonal immunoglobulins is important for the diagnosis and management of monoclonal gammopathies. We report a case of a 71 year old lady with a history of chronic gastritis and recurrent lower respiratory tract infection whereby no specific diagnosis was made until a computed tomography (CT) guided lung biopsy and orogastroduodenoscopy. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2011-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24524/1/Monoclonal%20gammopathy%20with%20systemic%20amylodosis%20an%20evaluation%20of%20diagnostic%20elements.pdf Chellappah Thambiah, Subashini and George, Elizabeth and Umar, Nor Aini (2011) Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements. Malaysian Journal of Medicine and Health Sciences, 7 (1). pp. 51-55. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2011V07N1_OP07.pdf |
| spellingShingle | Chellappah Thambiah, Subashini George, Elizabeth Umar, Nor Aini Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| title | Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| title_full | Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| title_fullStr | Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| title_full_unstemmed | Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| title_short | Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| title_sort | monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements |
| url | http://psasir.upm.edu.my/id/eprint/24524/ http://psasir.upm.edu.my/id/eprint/24524/ http://psasir.upm.edu.my/id/eprint/24524/1/Monoclonal%20gammopathy%20with%20systemic%20amylodosis%20an%20evaluation%20of%20diagnostic%20elements.pdf |