Induced pluripotent stem cells: history, properties and potential applications
The development of induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing debates surrounding human embryonic stem cells (hESC) research. The discovery reveals the fact...
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24522/ http://psasir.upm.edu.my/id/eprint/24522/1/Induced%20pluripotent%20stem%20cells.pdf |
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| author | Nordin, Norshariza Lai, Mei I. Veeracumarasivam, Abhinanyu Ramasamy, Rajesh Abdullah, Syahrilnizam Yeo, Wendy Wai Yeng Rosli, Rozita |
| author_facet | Nordin, Norshariza Lai, Mei I. Veeracumarasivam, Abhinanyu Ramasamy, Rajesh Abdullah, Syahrilnizam Yeo, Wendy Wai Yeng Rosli, Rozita |
| author_sort | Nordin, Norshariza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The development of induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing debates surrounding human embryonic stem cells (hESC) research. The discovery reveals the fact that embryonic pluripotency can be generated from adult somatic cells by the induction of appropriate transcriptional factor genes essential for maintaining the pluripotency. They provide an alternative source for pluripotent stem cells, thus representing a powerful new research tool besides their potential application in the field of regenerative medicine. In this review, the historical background of iPSCs generation will be discussed together with their properties and characteristics as well as their potential therapeutic applications. |
| first_indexed | 2025-11-15T08:40:48Z |
| format | Article |
| id | upm-24522 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:40:48Z |
| publishDate | 2011 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245222017-08-09T06:13:03Z http://psasir.upm.edu.my/id/eprint/24522/ Induced pluripotent stem cells: history, properties and potential applications Nordin, Norshariza Lai, Mei I. Veeracumarasivam, Abhinanyu Ramasamy, Rajesh Abdullah, Syahrilnizam Yeo, Wendy Wai Yeng Rosli, Rozita The development of induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing debates surrounding human embryonic stem cells (hESC) research. The discovery reveals the fact that embryonic pluripotency can be generated from adult somatic cells by the induction of appropriate transcriptional factor genes essential for maintaining the pluripotency. They provide an alternative source for pluripotent stem cells, thus representing a powerful new research tool besides their potential application in the field of regenerative medicine. In this review, the historical background of iPSCs generation will be discussed together with their properties and characteristics as well as their potential therapeutic applications. Malaysian Medical Association 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24522/1/Induced%20pluripotent%20stem%20cells.pdf Nordin, Norshariza and Lai, Mei I. and Veeracumarasivam, Abhinanyu and Ramasamy, Rajesh and Abdullah, Syahrilnizam and Yeo, Wendy Wai Yeng and Rosli, Rozita (2011) Induced pluripotent stem cells: history, properties and potential applications. Medical Journal of Malaysia, 66 (1). pp. 4-9. ISSN 0300-5283 http://www.e-mjm.org/2011/v66n1/index.html |
| spellingShingle | Nordin, Norshariza Lai, Mei I. Veeracumarasivam, Abhinanyu Ramasamy, Rajesh Abdullah, Syahrilnizam Yeo, Wendy Wai Yeng Rosli, Rozita Induced pluripotent stem cells: history, properties and potential applications |
| title | Induced pluripotent stem cells: history, properties and potential applications |
| title_full | Induced pluripotent stem cells: history, properties and potential applications |
| title_fullStr | Induced pluripotent stem cells: history, properties and potential applications |
| title_full_unstemmed | Induced pluripotent stem cells: history, properties and potential applications |
| title_short | Induced pluripotent stem cells: history, properties and potential applications |
| title_sort | induced pluripotent stem cells: history, properties and potential applications |
| url | http://psasir.upm.edu.my/id/eprint/24522/ http://psasir.upm.edu.my/id/eprint/24522/ http://psasir.upm.edu.my/id/eprint/24522/1/Induced%20pluripotent%20stem%20cells.pdf |