Aggressive variant large granular lymphocytic leukaemia: a case report
Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24511/ http://psasir.upm.edu.my/id/eprint/24511/1/Aggressive%20Variant%20Large%20Granular%20Lymphocytic%20Leukaemia%20A%20Case%20Report.pdf |
| _version_ | 1848845057373765632 |
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| author | Md Noor, Sabariah Seman, Zainina Idris, Faridah Leong, Chooi Fun |
| author_facet | Md Noor, Sabariah Seman, Zainina Idris, Faridah Leong, Chooi Fun |
| author_sort | Md Noor, Sabariah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or
identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt all standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant. This case highlights on both the classical laboratory findings of rare entity of disease as well as a review of the literature pertaining particularly on its management. |
| first_indexed | 2025-11-15T08:40:46Z |
| format | Article |
| id | upm-24511 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:40:46Z |
| publishDate | 2011 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245112015-09-08T03:51:53Z http://psasir.upm.edu.my/id/eprint/24511/ Aggressive variant large granular lymphocytic leukaemia: a case report Md Noor, Sabariah Seman, Zainina Idris, Faridah Leong, Chooi Fun Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively. Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt all standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant. This case highlights on both the classical laboratory findings of rare entity of disease as well as a review of the literature pertaining particularly on its management. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2011-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24511/1/Aggressive%20Variant%20Large%20Granular%20Lymphocytic%20Leukaemia%20A%20Case%20Report.pdf Md Noor, Sabariah and Seman, Zainina and Idris, Faridah and Leong, Chooi Fun (2011) Aggressive variant large granular lymphocytic leukaemia: a case report. Malaysian Journal of Medicine and Health Sciences, 7 (1). pp. 57-60. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2011V07N1_OP08.pdf |
| spellingShingle | Md Noor, Sabariah Seman, Zainina Idris, Faridah Leong, Chooi Fun Aggressive variant large granular lymphocytic leukaemia: a case report |
| title | Aggressive variant large granular lymphocytic leukaemia: a case report |
| title_full | Aggressive variant large granular lymphocytic leukaemia: a case report |
| title_fullStr | Aggressive variant large granular lymphocytic leukaemia: a case report |
| title_full_unstemmed | Aggressive variant large granular lymphocytic leukaemia: a case report |
| title_short | Aggressive variant large granular lymphocytic leukaemia: a case report |
| title_sort | aggressive variant large granular lymphocytic leukaemia: a case report |
| url | http://psasir.upm.edu.my/id/eprint/24511/ http://psasir.upm.edu.my/id/eprint/24511/ http://psasir.upm.edu.my/id/eprint/24511/1/Aggressive%20Variant%20Large%20Granular%20Lymphocytic%20Leukaemia%20A%20Case%20Report.pdf |