Development and characterisation study of liposomes-encapsulated piroxicam.
The objective of present work was to develop a novel liposomes-based drug delivery system for a lipophilic non-steroidal anti-inflammatory drug, piroxicam. The system was prepared using proliposomes method and optimised for different preparation parameters including type of proliposomes, concentrati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
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Advanced Research Journals
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24509/ http://psasir.upm.edu.my/id/eprint/24509/1/Development%20and%20characterisation%20study%20of%20liposomes.pdf |
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| author | Chiong, H. S. Abdullah, Muhammad Nazrul Hakim Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Ahmad, Zuraini Ong, S. G. M. Yuen, K. H. |
| author_facet | Chiong, H. S. Abdullah, Muhammad Nazrul Hakim Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Ahmad, Zuraini Ong, S. G. M. Yuen, K. H. |
| author_sort | Chiong, H. S. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The objective of present work was to develop a novel liposomes-based drug delivery system for a lipophilic non-steroidal anti-inflammatory drug, piroxicam. The system was prepared using proliposomes method and optimised for different preparation parameters including type of proliposomes, concentration of drug, duration of hydration and type of particle size reduction treatment used. All prepared liposomal samples were extensively characterized for their drug-entrapment and size profile using various in-vitro techniques. Present work showed that the most optimum formulation (Pro-lipoTM Duo; 12mg piroxicam per gram Pro-lipoTM; 10 hours hydration time) produced highest amount of actual drug been entrapped in liposomes (800.4 mg/g Pro-lipoTM) with a satisfactory entrapment efficiency of 15.36%. This formulation had also produced liposomal samples with a homogenous (polydispersity index = 0.45) and small particle size (359.95nm). Extrusion technique was found to cause significant reduction in drug-entrapment and size profile of drug-loaded liposomes. A 4-weeks storage study showed that drug-entrapment and size profile of liposomal samples were stable in both refrigerated and room temperature. Electron microscopy revealed that prepared liposomal samples were spherical-shaped and showed concentric lamellae. In conclusion, present work successfully demonstrated a simple, reproducible and practical method of preparation for liposomes-encapsulated piroxicam. |
| first_indexed | 2025-11-15T08:40:45Z |
| format | Article |
| id | upm-24509 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:40:45Z |
| publishDate | 2010 |
| publisher | Advanced Research Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-245092015-11-03T01:25:22Z http://psasir.upm.edu.my/id/eprint/24509/ Development and characterisation study of liposomes-encapsulated piroxicam. Chiong, H. S. Abdullah, Muhammad Nazrul Hakim Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Ahmad, Zuraini Ong, S. G. M. Yuen, K. H. The objective of present work was to develop a novel liposomes-based drug delivery system for a lipophilic non-steroidal anti-inflammatory drug, piroxicam. The system was prepared using proliposomes method and optimised for different preparation parameters including type of proliposomes, concentration of drug, duration of hydration and type of particle size reduction treatment used. All prepared liposomal samples were extensively characterized for their drug-entrapment and size profile using various in-vitro techniques. Present work showed that the most optimum formulation (Pro-lipoTM Duo; 12mg piroxicam per gram Pro-lipoTM; 10 hours hydration time) produced highest amount of actual drug been entrapped in liposomes (800.4 mg/g Pro-lipoTM) with a satisfactory entrapment efficiency of 15.36%. This formulation had also produced liposomal samples with a homogenous (polydispersity index = 0.45) and small particle size (359.95nm). Extrusion technique was found to cause significant reduction in drug-entrapment and size profile of drug-loaded liposomes. A 4-weeks storage study showed that drug-entrapment and size profile of liposomal samples were stable in both refrigerated and room temperature. Electron microscopy revealed that prepared liposomal samples were spherical-shaped and showed concentric lamellae. In conclusion, present work successfully demonstrated a simple, reproducible and practical method of preparation for liposomes-encapsulated piroxicam. Advanced Research Journals 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24509/1/Development%20and%20characterisation%20study%20of%20liposomes.pdf Chiong, H. S. and Abdullah, Muhammad Nazrul Hakim and Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Ong, S. G. M. and Yuen, K. H. (2010) Development and characterisation study of liposomes-encapsulated piroxicam. International Journal of Drug Delivery, 3 (1). pp. 64-73. ISSN 0975-0215 English |
| spellingShingle | Chiong, H. S. Abdullah, Muhammad Nazrul Hakim Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Ahmad, Zuraini Ong, S. G. M. Yuen, K. H. Development and characterisation study of liposomes-encapsulated piroxicam. |
| title | Development and characterisation study of liposomes-encapsulated piroxicam. |
| title_full | Development and characterisation study of liposomes-encapsulated piroxicam. |
| title_fullStr | Development and characterisation study of liposomes-encapsulated piroxicam. |
| title_full_unstemmed | Development and characterisation study of liposomes-encapsulated piroxicam. |
| title_short | Development and characterisation study of liposomes-encapsulated piroxicam. |
| title_sort | development and characterisation study of liposomes-encapsulated piroxicam. |
| url | http://psasir.upm.edu.my/id/eprint/24509/ http://psasir.upm.edu.my/id/eprint/24509/1/Development%20and%20characterisation%20study%20of%20liposomes.pdf |