In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension.
Introduction: This study was conducted to determine the inhibitory potential of selected Malaysian plants against key enzymes related to type 2 diabetes and hypertension. Methods: The samples investigated were pucuk ubi (Manihot esculenta), pucuk betik (Carica papaya), ulam raja (Cosmos caudatus)...
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| Format: | Article |
| Language: | English English |
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Nutrition Society of Malaysia
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24476/ http://psasir.upm.edu.my/id/eprint/24476/1/In%20vitro%20inhibitory%20potential%20of%20selected%20Malaysian%20plants%20against%20key%20enzymes%20involved%20in%20hyperglycemia%20and%20hypertension.pdf |
| _version_ | 1848845047778246656 |
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| author | Loh, Su Peng O., Hadira |
| author_facet | Loh, Su Peng O., Hadira |
| author_sort | Loh, Su Peng |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: This study was conducted to determine the inhibitory potential of
selected Malaysian plants against key enzymes related to type 2 diabetes and
hypertension. Methods: The samples investigated were pucuk ubi (Manihot
esculenta), pucuk betik (Carica papaya), ulam raja (Cosmos caudatus), pegaga (Centella
asiatica) and kacang botol (Psophocarpus tetragonolobus). The inhibitory potential of
hexane and dichloromethane extracts against the enzymes were determined by
using α-amylase, α-glucosidase and angiotensin I-converting enzyme (ACE)
inhibition assay. Results: In α-amylase inhibition assay, the inhibitory potential
was highest in pucuk ubi for both hexane (59.22%) and dichloromethane extract
(54.15%). Hexane extract of pucuk ubi (95.01%) and dichloromethane extract of
kacang botol (38.94%) showed the highest inhibitory potential against α-
glucosidase,while in ACE inhibition assay, the inhibitory potential was highest
in hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik
(59.77%). Conclusion: This study suggests a nutraceutical potential of some of
these plants for hyperglycemia and hypertension prevention associated with
type 2 diabetes. |
| first_indexed | 2025-11-15T08:40:37Z |
| format | Article |
| id | upm-24476 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:40:37Z |
| publishDate | 2011 |
| publisher | Nutrition Society of Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-244762015-10-05T01:46:37Z http://psasir.upm.edu.my/id/eprint/24476/ In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. Loh, Su Peng O., Hadira Introduction: This study was conducted to determine the inhibitory potential of selected Malaysian plants against key enzymes related to type 2 diabetes and hypertension. Methods: The samples investigated were pucuk ubi (Manihot esculenta), pucuk betik (Carica papaya), ulam raja (Cosmos caudatus), pegaga (Centella asiatica) and kacang botol (Psophocarpus tetragonolobus). The inhibitory potential of hexane and dichloromethane extracts against the enzymes were determined by using α-amylase, α-glucosidase and angiotensin I-converting enzyme (ACE) inhibition assay. Results: In α-amylase inhibition assay, the inhibitory potential was highest in pucuk ubi for both hexane (59.22%) and dichloromethane extract (54.15%). Hexane extract of pucuk ubi (95.01%) and dichloromethane extract of kacang botol (38.94%) showed the highest inhibitory potential against α- glucosidase,while in ACE inhibition assay, the inhibitory potential was highest in hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik (59.77%). Conclusion: This study suggests a nutraceutical potential of some of these plants for hyperglycemia and hypertension prevention associated with type 2 diabetes. Nutrition Society of Malaysia 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24476/1/In%20vitro%20inhibitory%20potential%20of%20selected%20Malaysian%20plants%20against%20key%20enzymes%20involved%20in%20hyperglycemia%20and%20hypertension.pdf Loh, Su Peng and O., Hadira (2011) In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. Malaysian Journal of Nutrition, 17 (1). pp. 77-86. ISSN 1394-035X http://www.nutriweb.org.my/publications/mjn0019_2/default.php English |
| spellingShingle | Loh, Su Peng O., Hadira In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| title | In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| title_full | In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| title_fullStr | In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| title_full_unstemmed | In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| title_short | In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| title_sort | in vitro inhibitory potential of selected malaysian plants against key enzymes involved in hyperglycemia and hypertension. |
| url | http://psasir.upm.edu.my/id/eprint/24476/ http://psasir.upm.edu.my/id/eprint/24476/ http://psasir.upm.edu.my/id/eprint/24476/1/In%20vitro%20inhibitory%20potential%20of%20selected%20Malaysian%20plants%20against%20key%20enzymes%20involved%20in%20hyperglycemia%20and%20hypertension.pdf |