Advancements in reprogramming strategies for the generation of induced pluripotent stem cells.
Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells has emerged as an invaluable method for generating patient-specific stem cells of any lineage without the use of embryonic materials. Following the first reported generation of iPS cells from murine fibroblasts using ret...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
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Springer
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24398/ http://psasir.upm.edu.my/id/eprint/24398/1/Advancements%20in%20reprogramming%20strategies%20for%20the%20generation%20of%20induced%20pluripotent%20stem%20cells.pdf |
| _version_ | 1848845025375420416 |
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| author | Lai, Mei I. Wai Yeng, Wendy Yeo Ramasamy, Rajesh Nordin, Norshariza Rosli, Rozita Veeracumarasivam, Abhinanyu Abdullah, Syahrilnizam |
| author_facet | Lai, Mei I. Wai Yeng, Wendy Yeo Ramasamy, Rajesh Nordin, Norshariza Rosli, Rozita Veeracumarasivam, Abhinanyu Abdullah, Syahrilnizam |
| author_sort | Lai, Mei I. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells has emerged as an invaluable method for generating patient-specific stem cells of any lineage without the use of embryonic materials. Following the first reported generation of iPS cells from murine fibroblasts using retroviral transduction of a defined set of transcription factors, various new strategies have been developed to improve and refine the reprogramming technology. Recent developments provide optimism that the generation of safe iPS cells without any genomic modification could be derived in the near future for the use in clinical settings. This review summarizes current and evolving strategies in the generation of iPS cells, including types of somatic cells for reprogramming, variations of reprogramming genes, reprogramming methods, and how the advancement iPS cells technology can lead to the future success of reproductive medicine. |
| first_indexed | 2025-11-15T08:40:15Z |
| format | Article |
| id | upm-24398 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:40:15Z |
| publishDate | 2011 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-243982015-10-05T00:51:21Z http://psasir.upm.edu.my/id/eprint/24398/ Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. Lai, Mei I. Wai Yeng, Wendy Yeo Ramasamy, Rajesh Nordin, Norshariza Rosli, Rozita Veeracumarasivam, Abhinanyu Abdullah, Syahrilnizam Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells has emerged as an invaluable method for generating patient-specific stem cells of any lineage without the use of embryonic materials. Following the first reported generation of iPS cells from murine fibroblasts using retroviral transduction of a defined set of transcription factors, various new strategies have been developed to improve and refine the reprogramming technology. Recent developments provide optimism that the generation of safe iPS cells without any genomic modification could be derived in the near future for the use in clinical settings. This review summarizes current and evolving strategies in the generation of iPS cells, including types of somatic cells for reprogramming, variations of reprogramming genes, reprogramming methods, and how the advancement iPS cells technology can lead to the future success of reproductive medicine. Springer 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24398/1/Advancements%20in%20reprogramming%20strategies%20for%20the%20generation%20of%20induced%20pluripotent%20stem%20cells.pdf Lai, Mei I. and Wai Yeng, Wendy Yeo and Ramasamy, Rajesh and Nordin, Norshariza and Rosli, Rozita and Veeracumarasivam, Abhinanyu and Abdullah, Syahrilnizam (2011) Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. Journal of Assisted Reproduction and Genetics, 28 (4). pp. 291-301. ISSN 1058-0468; ESSN: 1573-7330 10.1007/s10815-011-9552-6 English |
| spellingShingle | Lai, Mei I. Wai Yeng, Wendy Yeo Ramasamy, Rajesh Nordin, Norshariza Rosli, Rozita Veeracumarasivam, Abhinanyu Abdullah, Syahrilnizam Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| title | Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| title_full | Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| title_fullStr | Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| title_full_unstemmed | Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| title_short | Advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| title_sort | advancements in reprogramming strategies for the generation of induced pluripotent stem cells. |
| url | http://psasir.upm.edu.my/id/eprint/24398/ http://psasir.upm.edu.my/id/eprint/24398/ http://psasir.upm.edu.my/id/eprint/24398/1/Advancements%20in%20reprogramming%20strategies%20for%20the%20generation%20of%20induced%20pluripotent%20stem%20cells.pdf |