Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats.
Wounds are unavoidable events of life and arise due to agents that induce stress or injury. Wound has been a menace the world over and healing is a survival mechanism and represents an adaptation to the maintenance of normal anatomical structure and function. The objective of this study was to evalu...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academic Journals
2011
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/24158/ http://psasir.upm.edu.my/id/eprint/24158/1/Wound%20healing%20properties%20of%20Eucheuma%20cottonii%20extracts%20in%20Sprague.pdf |
| _version_ | 1848844958015946752 |
|---|---|
| author | Fard, S.G. Tan, R.T.R Mohamed, A.A. Goh, Yong Meng Syed Muhammad, Sharifah Kharidah Al-Jashamy, K.A. Mohamed, Suhaila |
| author_facet | Fard, S.G. Tan, R.T.R Mohamed, A.A. Goh, Yong Meng Syed Muhammad, Sharifah Kharidah Al-Jashamy, K.A. Mohamed, Suhaila |
| author_sort | Fard, S.G. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Wounds are unavoidable events of life and arise due to agents that induce stress or injury. Wound has been a menace the world over and healing is a survival mechanism and represents an adaptation to the maintenance of normal anatomical structure and function. The objective of this study was to evaluate the potential wound healing properties of ethanolic and aqueous extracts of Eucheuma cottonii. A two centimeter diameter of skin excision wound was made on normal rats. Treatment with honey (100 mg/kg body weight) was used as positive control and untreated rats as the negative control groups. Inflammation and proliferation phases of wound healing including wound contraction, re-epithelization and granulation tissue development were monitored. This study showed that both seaweed extracts increased the rate of wound contraction compared with the positive and negative control. Ethanolic extract of E. cottonii was more effective than the aqueous extract by 20% (P<0.05). Histopathological findings showed the ethanolic extracts enhanced epithelization and tissue granulation significantly compared with both control groups. E. cottonii possesses several antioxidant compounds, which may be responsible for the accelerated wound healing. The present study demonstrated that these seaweed extracts accelerated healing better if not comparable with honey. |
| first_indexed | 2025-11-15T08:39:11Z |
| format | Article |
| id | upm-24158 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:39:11Z |
| publishDate | 2011 |
| publisher | Academic Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-241582015-09-18T08:10:37Z http://psasir.upm.edu.my/id/eprint/24158/ Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. Fard, S.G. Tan, R.T.R Mohamed, A.A. Goh, Yong Meng Syed Muhammad, Sharifah Kharidah Al-Jashamy, K.A. Mohamed, Suhaila Wounds are unavoidable events of life and arise due to agents that induce stress or injury. Wound has been a menace the world over and healing is a survival mechanism and represents an adaptation to the maintenance of normal anatomical structure and function. The objective of this study was to evaluate the potential wound healing properties of ethanolic and aqueous extracts of Eucheuma cottonii. A two centimeter diameter of skin excision wound was made on normal rats. Treatment with honey (100 mg/kg body weight) was used as positive control and untreated rats as the negative control groups. Inflammation and proliferation phases of wound healing including wound contraction, re-epithelization and granulation tissue development were monitored. This study showed that both seaweed extracts increased the rate of wound contraction compared with the positive and negative control. Ethanolic extract of E. cottonii was more effective than the aqueous extract by 20% (P<0.05). Histopathological findings showed the ethanolic extracts enhanced epithelization and tissue granulation significantly compared with both control groups. E. cottonii possesses several antioxidant compounds, which may be responsible for the accelerated wound healing. The present study demonstrated that these seaweed extracts accelerated healing better if not comparable with honey. Academic Journals 2011-11-23 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24158/1/Wound%20healing%20properties%20of%20Eucheuma%20cottonii%20extracts%20in%20Sprague.pdf Fard, S.G. and Tan, R.T.R and Mohamed, A.A. and Goh, Yong Meng and Syed Muhammad, Sharifah Kharidah and Al-Jashamy, K.A. and Mohamed, Suhaila (2011) Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. Journal of Medicinal Plants Research, 5 (27). pp. 6373-6380. ISSN 1996-0875 http://www.academicjournals.org/ 10.5897/JMPR10.902 |
| spellingShingle | Fard, S.G. Tan, R.T.R Mohamed, A.A. Goh, Yong Meng Syed Muhammad, Sharifah Kharidah Al-Jashamy, K.A. Mohamed, Suhaila Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. |
| title | Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. |
| title_full | Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. |
| title_fullStr | Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. |
| title_full_unstemmed | Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. |
| title_short | Wound healing properties of Eucheuma cottonii extracts in Sprague-Dawley rats. |
| title_sort | wound healing properties of eucheuma cottonii extracts in sprague-dawley rats. |
| url | http://psasir.upm.edu.my/id/eprint/24158/ http://psasir.upm.edu.my/id/eprint/24158/ http://psasir.upm.edu.my/id/eprint/24158/ http://psasir.upm.edu.my/id/eprint/24158/1/Wound%20healing%20properties%20of%20Eucheuma%20cottonii%20extracts%20in%20Sprague.pdf |