Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions.
A simplex centroid mixture design was used to study the interactions between two chosen solvents, dichloromethane (DCM) and acetone (ACT), as organic-phase components in the formation and physicochemical characterization and cellular uptake of astaxanthin nanodispersions produced using precipitatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/24093/ http://psasir.upm.edu.my/id/eprint/24093/1/Effect%20of%20organic.pdf |
| _version_ | 1848844940134580224 |
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| author | Anarjan, Navideh Tan, Chin Ping Tau, Chuan Ling Kwan, Liang Lye Malmiri, Hoda Jafarizadeh Nehdi, Imededdine Arbi Cheah, Yoke Kqueen Mirhosseini, Hamed Sham Baharin, Badlishah |
| author_facet | Anarjan, Navideh Tan, Chin Ping Tau, Chuan Ling Kwan, Liang Lye Malmiri, Hoda Jafarizadeh Nehdi, Imededdine Arbi Cheah, Yoke Kqueen Mirhosseini, Hamed Sham Baharin, Badlishah |
| author_sort | Anarjan, Navideh |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A simplex centroid mixture design was used to study the interactions between two chosen solvents, dichloromethane (DCM) and acetone (ACT), as organic-phase components in the formation and physicochemical characterization and cellular uptake of astaxanthin nanodispersions produced using precipitation and condensation processes. Full cubic or quadratic regression models with acceptable determination coefficients were obtained for all of the studied responses. Multiple-response optimization predicted that the organic phase with 38% (w/w) DCM and 62% (w/w) ACT yielded astaxanthin nanodispersions with the minimum particle size (106 nm), polydispersity index (0.191), and total astaxanthin loss (12.7%, w/w) and the maximum cellular uptake (2981 fmol/cell). Astaxanthin cellular uptake from the produced nanodispersions also showed a good correlation with their particle size distributions and astaxanthin trans/cis isomerization ratios. The absence of significant (p > 0.05) differences between the experimental and predicted values of the response variables confirmed the adequacy of the fitted models. |
| first_indexed | 2025-11-15T08:38:54Z |
| format | Article |
| id | upm-24093 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:38:54Z |
| publishDate | 2011 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-240932016-02-10T03:20:54Z http://psasir.upm.edu.my/id/eprint/24093/ Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. Anarjan, Navideh Tan, Chin Ping Tau, Chuan Ling Kwan, Liang Lye Malmiri, Hoda Jafarizadeh Nehdi, Imededdine Arbi Cheah, Yoke Kqueen Mirhosseini, Hamed Sham Baharin, Badlishah A simplex centroid mixture design was used to study the interactions between two chosen solvents, dichloromethane (DCM) and acetone (ACT), as organic-phase components in the formation and physicochemical characterization and cellular uptake of astaxanthin nanodispersions produced using precipitation and condensation processes. Full cubic or quadratic regression models with acceptable determination coefficients were obtained for all of the studied responses. Multiple-response optimization predicted that the organic phase with 38% (w/w) DCM and 62% (w/w) ACT yielded astaxanthin nanodispersions with the minimum particle size (106 nm), polydispersity index (0.191), and total astaxanthin loss (12.7%, w/w) and the maximum cellular uptake (2981 fmol/cell). Astaxanthin cellular uptake from the produced nanodispersions also showed a good correlation with their particle size distributions and astaxanthin trans/cis isomerization ratios. The absence of significant (p > 0.05) differences between the experimental and predicted values of the response variables confirmed the adequacy of the fitted models. American Chemical Society 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24093/1/Effect%20of%20organic.pdf Anarjan, Navideh and Tan, Chin Ping and Tau, Chuan Ling and Kwan, Liang Lye and Malmiri, Hoda Jafarizadeh and Nehdi, Imededdine Arbi and Cheah, Yoke Kqueen and Mirhosseini, Hamed and Sham Baharin, Badlishah (2011) Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. Journal of Agricultural and Food Chemistry, 59 (16). pp. 8733-8741. ISSN 0021-8561 http://dx.doi.org/10.1021/jf201314u 10.1021/jf201314u |
| spellingShingle | Anarjan, Navideh Tan, Chin Ping Tau, Chuan Ling Kwan, Liang Lye Malmiri, Hoda Jafarizadeh Nehdi, Imededdine Arbi Cheah, Yoke Kqueen Mirhosseini, Hamed Sham Baharin, Badlishah Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| title | Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| title_full | Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| title_fullStr | Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| title_full_unstemmed | Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| title_short | Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| title_sort | effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions. |
| url | http://psasir.upm.edu.my/id/eprint/24093/ http://psasir.upm.edu.my/id/eprint/24093/ http://psasir.upm.edu.my/id/eprint/24093/ http://psasir.upm.edu.my/id/eprint/24093/1/Effect%20of%20organic.pdf |