Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing.
Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/23849/ http://psasir.upm.edu.my/id/eprint/23849/1/Effects%20of%20micro.pdf |
| _version_ | 1848844873110650880 |
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| author | Mohd Ikhsan, Natrah Fatin Kenmegne, Mireille Mardel Wiyoto, Wiyoto Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom |
| author_facet | Mohd Ikhsan, Natrah Fatin Kenmegne, Mireille Mardel Wiyoto, Wiyoto Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom |
| author_sort | Mohd Ikhsan, Natrah Fatin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acyl-homoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains. |
| first_indexed | 2025-11-15T08:37:50Z |
| format | Article |
| id | upm-23849 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:37:50Z |
| publishDate | 2011 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-238492015-10-16T06:57:13Z http://psasir.upm.edu.my/id/eprint/23849/ Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. Mohd Ikhsan, Natrah Fatin Kenmegne, Mireille Mardel Wiyoto, Wiyoto Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acyl-homoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains. Elsevier 2011-07-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/23849/1/Effects%20of%20micro.pdf Mohd Ikhsan, Natrah Fatin and Kenmegne, Mireille Mardel and Wiyoto, Wiyoto and Sorgeloos, Patrick and Bossier, Peter and Defoirdt, Tom (2011) Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. Aquaculture, 317 (1). pp. 53-57. ISSN 0044-8486 http://www.elsevier.com/ English |
| spellingShingle | Mohd Ikhsan, Natrah Fatin Kenmegne, Mireille Mardel Wiyoto, Wiyoto Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| title | Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| title_full | Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| title_fullStr | Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| title_full_unstemmed | Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| title_short | Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| title_sort | effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. |
| url | http://psasir.upm.edu.my/id/eprint/23849/ http://psasir.upm.edu.my/id/eprint/23849/ http://psasir.upm.edu.my/id/eprint/23849/1/Effects%20of%20micro.pdf |