Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia
Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. T...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/22165/ http://psasir.upm.edu.my/id/eprint/22165/1/95.%20Ethnic%20Differences%20in%20the%20Prevalence%2C%20Clinical%20Outcome%20and.pdf |
| _version_ | 1848844410014400512 |
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| author | Hamat, Rukman Awang Embran, Nor Amalina Sekawi, Zamberi Osman, Malina Hanafiah, Alfizah Abdul Manaf, Mohd Rizal Adnan, Aminuddin Mohamed, Ramelah |
| author_facet | Hamat, Rukman Awang Embran, Nor Amalina Sekawi, Zamberi Osman, Malina Hanafiah, Alfizah Abdul Manaf, Mohd Rizal Adnan, Aminuddin Mohamed, Ramelah |
| author_sort | Hamat, Rukman Awang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. The Indians had the highest prevalence of H. pylori infection among other ethnic groups (Malays= 8.6 %, Chinese= 24.3 %, Indians= 33.9%). cagM and cagT were the most predominant genes found (63.4% for each), followed by cagA (62.2 %), cagE (48.2%), cag6-7 (46.3%), cag10 (42.1%), cag13 (4.9%) and IS605 (3.7%). No significant association was found between H. pylori infection and H. pylori genes with ethnic groups or clinical outcomes. Indians who had a combination of cagA/ E/M genes of H. pylori were likely to be associated with 21-time of having non-ulcer dyspepsia (NUD) than peptic ulcer disease (PUD). Therefore, these genes may serve as useful markers in predicting the clinical presentation of a H. pylori infection among Indians in our studied population. Hence, this preliminary data might explain why Indians have a low prevalence of gastric cancer and peptic ulcer disease despite having persistently high prevalence of H. pylori infection for many decades (“Indian enigma�) in Malaysian patients. |
| first_indexed | 2025-11-15T08:30:28Z |
| format | Article |
| id | upm-22165 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:30:28Z |
| publishDate | 2013 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-221652015-11-24T08:53:48Z http://psasir.upm.edu.my/id/eprint/22165/ Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia Hamat, Rukman Awang Embran, Nor Amalina Sekawi, Zamberi Osman, Malina Hanafiah, Alfizah Abdul Manaf, Mohd Rizal Adnan, Aminuddin Mohamed, Ramelah Different Helicobacter pylori genes may be well conserved within different ethnic groups and could give rise to different clinical outcomes. In this study, we demonstrated a low prevalence of H. pylori infection (19.2%) which is in concordance with the current trend demostrated locally and abroad. The Indians had the highest prevalence of H. pylori infection among other ethnic groups (Malays= 8.6 %, Chinese= 24.3 %, Indians= 33.9%). cagM and cagT were the most predominant genes found (63.4% for each), followed by cagA (62.2 %), cagE (48.2%), cag6-7 (46.3%), cag10 (42.1%), cag13 (4.9%) and IS605 (3.7%). No significant association was found between H. pylori infection and H. pylori genes with ethnic groups or clinical outcomes. Indians who had a combination of cagA/ E/M genes of H. pylori were likely to be associated with 21-time of having non-ulcer dyspepsia (NUD) than peptic ulcer disease (PUD). Therefore, these genes may serve as useful markers in predicting the clinical presentation of a H. pylori infection among Indians in our studied population. Hence, this preliminary data might explain why Indians have a low prevalence of gastric cancer and peptic ulcer disease despite having persistently high prevalence of H. pylori infection for many decades (“Indian enigma�) in Malaysian patients. Universiti Putra Malaysia Press 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22165/1/95.%20Ethnic%20Differences%20in%20the%20Prevalence%2C%20Clinical%20Outcome%20and.pdf Hamat, Rukman Awang and Embran, Nor Amalina and Sekawi, Zamberi and Osman, Malina and Hanafiah, Alfizah and Abdul Manaf, Mohd Rizal and Adnan, Aminuddin and Mohamed, Ramelah (2013) Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia. Pertanika Journal of Tropical Agricultural Science, 36 (4). pp. 289-298. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2036%20(4)%20Nov.%202013/01%20Page%20289-298.pdf |
| spellingShingle | Hamat, Rukman Awang Embran, Nor Amalina Sekawi, Zamberi Osman, Malina Hanafiah, Alfizah Abdul Manaf, Mohd Rizal Adnan, Aminuddin Mohamed, Ramelah Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia |
| title | Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia |
| title_full | Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia |
| title_fullStr | Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia |
| title_full_unstemmed | Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia |
| title_short | Ethnic differences in the prevalence, clinical outcome and cag Pathogenicity Island (cagPAI) virulence gene profiles of Helicobacter pylori strains from Malaysia |
| title_sort | ethnic differences in the prevalence, clinical outcome and cag pathogenicity island (cagpai) virulence gene profiles of helicobacter pylori strains from malaysia |
| url | http://psasir.upm.edu.my/id/eprint/22165/ http://psasir.upm.edu.my/id/eprint/22165/ http://psasir.upm.edu.my/id/eprint/22165/1/95.%20Ethnic%20Differences%20in%20the%20Prevalence%2C%20Clinical%20Outcome%20and.pdf |