Transgene Silencing Following Lentiviral Gene Delivery into Hematopoietic Stem Cells

QR Code

Transgene Silencing Following Lentiviral Gene Delivery into Hematopoietic Stem Cells

Gene therapy shows increasing promise for the treatment of hematopoietic inherited diseases such as β-thalassemia. One of the main barriers for a successful gene therapy is the short-lived duration of gene expression in vivo, a phenomenon known as transgene silencing. Unlike other viral methods, len...

Full description

Bibliographic Details
Main Author:	Ngai, Siew Chang
Format:	Thesis
Language:	English English
Published:	2011
Subjects:	Hematopoiesis
Online Access:	http://psasir.upm.edu.my/id/eprint/21839/ http://psasir.upm.edu.my/id/eprint/21839/1/FPSK%28p%29_2011_7IR.pdf

Similar Items

Transgene expression from CpG-reduced lentiviral gene delivery vectors in vitro
by: Low, Poh Tee, et al.
Published: (2014)

Mitogenic activity of mesenchymal stem cells on hematopoietic stem cells via cellular analysis and gene expression
by: Mohadeseh, Hashem Boroojerdi
Published: (2015)

Evaluation of lentiviral based gene delivery system in adherent and suspension in vitro cell models
by: Izyan Mohd Idris,, et al.
Published: (2024)

Evaluation of lentiviral based gene delivery system in adherent and suspension in vitro cell models
by: Mohd Idris, Izyan, et al.
Published: (2024)

Evaluation of lentiviral based gene delivery system in adherent and suspension in vitro cell models
by: Mohd Idris, Izyan, et al.
Published: (2024)

Lack of methylation on transgene leads to high level and persistent transgene expression in induced pluripotent stem cells
by: Alhaji, Suleiman Yusuf, et al.
Published: (2020)

Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells
by: Lebert-Ghali, Charles-Étienne, et al.
Published: (2016)

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
by: Lim, Wai Feng, et al.
Published: (2013)

Production of lentiviral vector with polycistronic transcripts for reprogramming of mouse fibroblast cells
by: Al Abbar, Akram, et al.
Published: (2018)

Effects of mild gestational diabetes mellitus on quality of umbilical cord blood hematopoietic stem cells procured at delivery
by: Ahmed, Sara. M.El.
Published: (2018)

Directional capacity of human mesenchymal stem cells to support hematopoietic stem cell proliferation in vitro
by: Boroojerdi, Mohadese Hashem, et al.
Published: (2022)

The uses of hematopoietic stem cell transplantation to restore the production of blood cells in cancer treatment
by: Abu Hashim, Nur Athirah, et al.
Published: (2022)

The combined influence of substrate elasticity and surface-grafted molecules on the exvivo expansion of hematopoietic stem and progenitor cells
by: Kumar, Suresh, et al.
Published: (2013)

Effects of gestational diabetes mellitus on the quality and quantity of blood hematopoietic stem cells: a case-control study
by: Tusimin, Maiza, et al.
Published: (2021)

Generation of induced pluripotent stem cells by a polycistronic lentiviral vector in feeder- and serum- free defined culture
by: Al Abbar, Akram Faisal Mahmaud, et al.
Published: (2018)

Generation of mouse induced pluripotent stem cells using polycistronic lentiviral vector in feeder - and serum-free culture
by: Mahmaud, Akram Faisal
Published: (2015)

Evaluation of anti-cancer function in natural killer cells generated from rat hematopoietic stem cells / Alireza Pirahmadian
by: Alireza , Pirahmadian
Published: (2020)

Lentiviral tracking of vascular differentiation in bone marrow progenitor cells
by: Schmeckpeper, J., et al.
Published: (2009)

Effect of N-acetylcysteine supplementation on oxidative stress-mediated cryoinjury of bone marrow derived-hematopoietic stem cells
by: Shawal Maradona Abdul Wahab,, et al.
Published: (2019)

The efficiency of cell sorting and harvesting methods for in vitro expansion of human umbilical cord blood derived CD34+ hematopoietic stem cells
by: Borojerdi, Mohadese Hashem, et al.
Published: (2015)

Generation of hemophilia A mouse induced pluripotent stem cells using polycistronic lentiviral vector in serum- and feeder-free culture conditions
by: M. Sakri, Rozita, et al.
Published: (2016)

Dynamics of epigenetic control on transgene expression mediated by lentivirus in mouse pluripotent stem cells
by: Alhaji, Suleiman Yusuf
Published: (2018)

PAMAM dendrimer roles in gene delivery methods and stem cell research
by: Daneshvar, Nasibeh, et al.
Published: (2013)

Expression of potential stem cell-related markers in acute myeloid leukaemia cell lines and gene silencing effect of HOXA3 in THP-1 cells
by: Panneerselvan, Hindhuja
Published: (2021)

Gene silencing approaches for the management of dyslipidaemia
by: Norata, Giuseppe, et al.
Published: (2013)

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors
by: Ahmed, B.Y., et al.
Published: (2004)

Modifications Of Nk-92mi Cell Line Through Third Generation Lentiviral Vector
by: Chin, Ding Sheng
Published: (2023)

Tumour suppressive effects of WEE1 gene silencing in breast cancer cells.
by: Ghiasi, Naghmeh, et al.
Published: (2013)

Pegylated granulocyte colony stimulating factor versus nonpegylated granulocyte colony stimulating factor for patients after hematopoietic stem cell transplantation (Protocol)
by: Kuan, Jew-Win, et al.
Published: (2012)

Optimisation of Delivery of the Ataxia Telangiectasia Mutated Transgene to HeLa Cells Using Glycosaminoglycan Enhanced Transduction
by: Siam, Ala'a
Published: (2021)

Acts of resistance: Breaking the silence of grief following crash fatalities
by: Breen, L., et al.
Published: (2010)

Construction of a doxycycline inducible adipogenic lentiviral expression system
by: Liu, Q., et al.
Published: (2013)

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines
by: Noor, Dzul Azri Mohamed, et al.
Published: (2016)

Hepatitis B virus-like particle: targeted delivery of plasmid expressing short hairpin RNA for silencing the Bcl-2 gene in cervical cancer cells
by: Akwiditya, Made Angga, et al.
Published: (2021)

Targeted delivery of short hairpin RNA expressing plasmid using hepatitis B virus-like particle for bcl-2 gene silencing in cervical cancer cells
by: Akwiditya, Made Angga
Published: (2021)

Silence and silencing: the case of trafficked women
by: Haezreena Begum Abdul Hamid,
Published: (2019)

Infectious hematopoietic necrosis virus: advances in diagnosis and vaccine development
by: Chean, Yeah Yong, et al.
Published: (2019)

Corrigendum: mitigation of sodium iodate-induced cytotoxicity in retinal pigment epithelial cells in vitro by transgenic erythropoietin-expressing mesenchymal stem cells
by: Koh, Avin Ee Hwan, et al.
Published: (2021)

Blood use in patients receiving intensive chemotherapy for acute leukemia or hematopoietic stem cell transplantation: the impact of a health system–wide patient blood management program
by: Leahy, M., et al.
Published: (2017)

Biodegradable microparticle for stem cell delivery and differentiation
by: Sukmawati, Anita
Published: (2013)