Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells in vitro. We investigated the effects of Piroxicam and mefenamic acid on the viabili...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Medwell Publishing
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17740/ |
| _version_ | 1848843326014357504 |
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| author | Somchit, M.N Ahmad, Zuraini Hussain, Mohd Khairi Ab. Hamid, Hasiah Zakaria, Zainul Amiruddin S, Faizah |
| author_facet | Somchit, M.N Ahmad, Zuraini Hussain, Mohd Khairi Ab. Hamid, Hasiah Zakaria, Zainul Amiruddin S, Faizah |
| author_sort | Somchit, M.N |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells in vitro. We investigated the effects of Piroxicam and mefenamic acid on the viability of 4 cancer cell lines in which 2 of them are colon cancer cell lines (HCT 116 and CaCo-2). Cell viability was determined using MTT assay. Both NSAIDs was observed to markedly decrease the cell viability of both cell lines (HCT 116 and CaCo-2). Piroxicam was statistically more cytotoxic towards the cancer cell lines when compared to mefenamic acid. However, the cytotoxic effect of NSAIDs was less potent on breast cancer cells (MCF-7) and liver cancer cells (Hep G2). In conclusion, piroxicam and mefenamic acid showed selective cytotoxic effects against colon cancer cells but not against liver or breast cancer cells. |
| first_indexed | 2025-11-15T08:13:15Z |
| format | Article |
| id | upm-17740 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:13:15Z |
| publishDate | 2009 |
| publisher | Medwell Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-177402012-08-08T03:22:43Z http://psasir.upm.edu.my/id/eprint/17740/ Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. Somchit, M.N Ahmad, Zuraini Hussain, Mohd Khairi Ab. Hamid, Hasiah Zakaria, Zainul Amiruddin S, Faizah Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells in vitro. We investigated the effects of Piroxicam and mefenamic acid on the viability of 4 cancer cell lines in which 2 of them are colon cancer cell lines (HCT 116 and CaCo-2). Cell viability was determined using MTT assay. Both NSAIDs was observed to markedly decrease the cell viability of both cell lines (HCT 116 and CaCo-2). Piroxicam was statistically more cytotoxic towards the cancer cell lines when compared to mefenamic acid. However, the cytotoxic effect of NSAIDs was less potent on breast cancer cells (MCF-7) and liver cancer cells (Hep G2). In conclusion, piroxicam and mefenamic acid showed selective cytotoxic effects against colon cancer cells but not against liver or breast cancer cells. Medwell Publishing 2009 Article PeerReviewed Somchit, M.N and Ahmad, Zuraini and Hussain, Mohd Khairi and Ab. Hamid, Hasiah and Zakaria, Zainul Amiruddin and S, Faizah (2009) Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. Research Journal of Pharmacology, 3 (1). pp. 15-18. ISSN 1815-9362 / Online ISSN : 1993-6019 http://www.medwelljournals.com/journalhome.php?jid=1815-9362 Nonsteroidal anti-inflammatory agents. Piroxicam. Mefenamic acid. English |
| spellingShingle | Nonsteroidal anti-inflammatory agents. Piroxicam. Mefenamic acid. Somchit, M.N Ahmad, Zuraini Hussain, Mohd Khairi Ab. Hamid, Hasiah Zakaria, Zainul Amiruddin S, Faizah Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| title | Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| title_full | Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| title_fullStr | Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| title_full_unstemmed | Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| title_short | Selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| title_sort | selective in vitro cytotoxic effects of piroxicam and mefenamic acid on several cancer cells lines. |
| topic | Nonsteroidal anti-inflammatory agents. Piroxicam. Mefenamic acid. |
| url | http://psasir.upm.edu.my/id/eprint/17740/ http://psasir.upm.edu.my/id/eprint/17740/ |