Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice
Aims: To assess the safety of Bifidobacterium pseudocatenulatum G4 in BALB/c mice that involves examination of bacterial translocation, changes in the internal organs and histology of the intestinal lining. Methods and Results: Forty male BALB/c mice were randomly assigned into five groups (n =...
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| Format: | Article |
| Language: | English English |
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2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17739/ http://psasir.upm.edu.my/id/eprint/17739/1/Safety%20evaluation%20of%20Bifidobacterium%20pseudocatenulatum%20G4%20as%20assessed%20in%20BALB.pdf |
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| author | Kabeir, Barka M. Abd.Manap, Mohd. Yazid Wong, Stephenie Yoke Wei Abdullah, Muhammad Nazrul Hakim Othaman, Muhammad Anas Mustafa, Shuhaimi |
| author_facet | Kabeir, Barka M. Abd.Manap, Mohd. Yazid Wong, Stephenie Yoke Wei Abdullah, Muhammad Nazrul Hakim Othaman, Muhammad Anas Mustafa, Shuhaimi |
| author_sort | Kabeir, Barka M. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Aims: To assess the safety of Bifidobacterium pseudocatenulatum G4 in BALB/c mice that involves examination of bacterial translocation, changes in the internal organs and histology of the intestinal lining.
Methods and Results: Forty male BALB/c mice were randomly assigned into five groups (n = 8). Three groups were orally fed with 50 μl of three different concentrations of B. pseudocatenulatum G4 (2 × 104, 1 × 108 and 1 × 1011 CFU day−1) for 4 weeks. One group was orally administered with 50 μl of 1 × 108 CFU B. longum BB536 per day for 4 weeks and last group was used as a nonbifidobacterial treatment control, which received 50 μl of skim milk. The administered strains did not affect the general health of mice and incapable of carrying out translocation to blood or liver. There were no significant differences in the internal organ (liver, heart, kidney and spleen) indices, serum enzymes of liver (aspartate aminotransferase, alkaline phosphate, alanine aminotransferase) and kidney (urea and creatinine) and histology (villi height, crypts height, mucosa thickness and epithelial cell height) of caecum, ileum and colon.
Conclusion: Administration of high dose of up to 1 × 1011 CFU B. pseudocatenulatum G4 per day to mice did not show any health threatening symptoms.
Significance and Impact of the Study: Bifidobacterium pseudocatenulatum G4 is none pathogenic to BALB/c mice and could be safe probiotic for human consumption. |
| first_indexed | 2025-11-15T08:13:14Z |
| format | Article |
| id | upm-17739 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:13:14Z |
| publishDate | 2008 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-177392015-09-28T04:05:50Z http://psasir.upm.edu.my/id/eprint/17739/ Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice Kabeir, Barka M. Abd.Manap, Mohd. Yazid Wong, Stephenie Yoke Wei Abdullah, Muhammad Nazrul Hakim Othaman, Muhammad Anas Mustafa, Shuhaimi Aims: To assess the safety of Bifidobacterium pseudocatenulatum G4 in BALB/c mice that involves examination of bacterial translocation, changes in the internal organs and histology of the intestinal lining. Methods and Results: Forty male BALB/c mice were randomly assigned into five groups (n = 8). Three groups were orally fed with 50 μl of three different concentrations of B. pseudocatenulatum G4 (2 × 104, 1 × 108 and 1 × 1011 CFU day−1) for 4 weeks. One group was orally administered with 50 μl of 1 × 108 CFU B. longum BB536 per day for 4 weeks and last group was used as a nonbifidobacterial treatment control, which received 50 μl of skim milk. The administered strains did not affect the general health of mice and incapable of carrying out translocation to blood or liver. There were no significant differences in the internal organ (liver, heart, kidney and spleen) indices, serum enzymes of liver (aspartate aminotransferase, alkaline phosphate, alanine aminotransferase) and kidney (urea and creatinine) and histology (villi height, crypts height, mucosa thickness and epithelial cell height) of caecum, ileum and colon. Conclusion: Administration of high dose of up to 1 × 1011 CFU B. pseudocatenulatum G4 per day to mice did not show any health threatening symptoms. Significance and Impact of the Study: Bifidobacterium pseudocatenulatum G4 is none pathogenic to BALB/c mice and could be safe probiotic for human consumption. 2008-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17739/1/Safety%20evaluation%20of%20Bifidobacterium%20pseudocatenulatum%20G4%20as%20assessed%20in%20BALB.pdf Kabeir, Barka M. and Abd.Manap, Mohd. Yazid and Wong, Stephenie Yoke Wei and Abdullah, Muhammad Nazrul Hakim and Othaman, Muhammad Anas and Mustafa, Shuhaimi (2008) Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice. Letters in Applied Microbiology, 46 (1). pp. 32-37. Bifidobacterium Mice - Infection 10.1111/j.1472-765X.2007.02255.x English |
| spellingShingle | Bifidobacterium Mice - Infection Kabeir, Barka M. Abd.Manap, Mohd. Yazid Wong, Stephenie Yoke Wei Abdullah, Muhammad Nazrul Hakim Othaman, Muhammad Anas Mustafa, Shuhaimi Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice |
| title | Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice |
| title_full | Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice |
| title_fullStr | Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice |
| title_full_unstemmed | Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice |
| title_short | Safety evaluation of Bifidobacterium pseudocatenulatum G4 as assessed in BALB/c mice |
| title_sort | safety evaluation of bifidobacterium pseudocatenulatum g4 as assessed in balb/c mice |
| topic | Bifidobacterium Mice - Infection |
| url | http://psasir.upm.edu.my/id/eprint/17739/ http://psasir.upm.edu.my/id/eprint/17739/ http://psasir.upm.edu.my/id/eprint/17739/1/Safety%20evaluation%20of%20Bifidobacterium%20pseudocatenulatum%20G4%20as%20assessed%20in%20BALB.pdf |