Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level
Initiation of acetaminophen (APAP) toxicities is believed to be promoted by oxidative stress during the event of overdosage. The aim of the present study was to evaluate the hepatoprotective action of Moringa oleifera Lam (MO), an Asian plant of high medicinal value, against a single high dose of AP...
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| Format: | Article |
| Language: | English English |
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Elsevier
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17726/ http://psasir.upm.edu.my/id/eprint/17726/1/Moringa%20oleifera%20Lam%20prevents%20acetaminophen%20induced%20liver%20injury%20through%20restoration%20of%20glutathione%20level.pdf |
| _version_ | 1848843322195443712 |
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| author | Fakurazi, Sharida Ithnin, Hairuszah U, Nanthini |
| author_facet | Fakurazi, Sharida Ithnin, Hairuszah U, Nanthini |
| author_sort | Fakurazi, Sharida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Initiation of acetaminophen (APAP) toxicities is believed to be promoted by oxidative stress during the event of overdosage. The aim of the present study was to evaluate the hepatoprotective action of Moringa oleifera Lam (MO), an Asian plant of high medicinal value, against a single high dose of APAP. Groups of five male Sprague–Dawley rats were pre-administered with MO (200 and 800 mg/kg) prior to a single dose of APAP (3 g/kg body weight; p.o). Silymarin was used as an established hepatoprotective drug against APAP induced liver injury. The hepatoprotective activity of MO extract was observed following significant histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in groups pretreated with MO compared to those treated with APAP alone. Meanwhile, the level of glutathione (GSH) was found to be restored in MO-treated animals compared to the groups treated with APAP alone. These observations were comparable
to the group pretreated with silymarin prior to APAP administration. Group that was treated with APAP alone exhibited high level of transaminases and ALP activities besides reduction in the GSH level. The histological hepatocellular deterioration was also evidenced. The results from the present study suggested that the leaves of MO can prevent hepatic injuries from APAP induced through preventing the decline of glutathione level. |
| first_indexed | 2025-11-15T08:13:11Z |
| format | Article |
| id | upm-17726 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:13:11Z |
| publishDate | 2008 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-177262015-10-06T07:07:33Z http://psasir.upm.edu.my/id/eprint/17726/ Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level Fakurazi, Sharida Ithnin, Hairuszah U, Nanthini Initiation of acetaminophen (APAP) toxicities is believed to be promoted by oxidative stress during the event of overdosage. The aim of the present study was to evaluate the hepatoprotective action of Moringa oleifera Lam (MO), an Asian plant of high medicinal value, against a single high dose of APAP. Groups of five male Sprague–Dawley rats were pre-administered with MO (200 and 800 mg/kg) prior to a single dose of APAP (3 g/kg body weight; p.o). Silymarin was used as an established hepatoprotective drug against APAP induced liver injury. The hepatoprotective activity of MO extract was observed following significant histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in groups pretreated with MO compared to those treated with APAP alone. Meanwhile, the level of glutathione (GSH) was found to be restored in MO-treated animals compared to the groups treated with APAP alone. These observations were comparable to the group pretreated with silymarin prior to APAP administration. Group that was treated with APAP alone exhibited high level of transaminases and ALP activities besides reduction in the GSH level. The histological hepatocellular deterioration was also evidenced. The results from the present study suggested that the leaves of MO can prevent hepatic injuries from APAP induced through preventing the decline of glutathione level. Elsevier 2008-04-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17726/1/Moringa%20oleifera%20Lam%20prevents%20acetaminophen%20induced%20liver%20injury%20through%20restoration%20of%20glutathione%20level.pdf Fakurazi, Sharida and Ithnin, Hairuszah and U, Nanthini (2008) Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food and Chemical Toxicology, 46 (8). pp. 2611-2615. ISSN 0278-6915 & ESSN: 1873-6351 http://www.sciencedirect.com/science/journal/02786915/46/8 Moringa oleifera Acetaminophen 10.1016/j.fct.2008.04.018 English |
| spellingShingle | Moringa oleifera Acetaminophen Fakurazi, Sharida Ithnin, Hairuszah U, Nanthini Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| title | Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| title_full | Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| title_fullStr | Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| title_full_unstemmed | Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| title_short | Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| title_sort | moringa oleifera lam prevents acetaminophen induced liver injury through restoration of glutathione level |
| topic | Moringa oleifera Acetaminophen |
| url | http://psasir.upm.edu.my/id/eprint/17726/ http://psasir.upm.edu.my/id/eprint/17726/ http://psasir.upm.edu.my/id/eprint/17726/ http://psasir.upm.edu.my/id/eprint/17726/1/Moringa%20oleifera%20Lam%20prevents%20acetaminophen%20induced%20liver%20injury%20through%20restoration%20of%20glutathione%20level.pdf |