Zerumbone : A Natural Compound with Anti-Cholinesterase Activity.
Herbal drugs could be a new source for inhibitors of acetyl cholinesterase (anti-AChE), the key enzyme in the breakdown of acetylcholine and a new talented approach for the cure of elderly neurologically associated disorders such as Alzheimer's disease (AD). Zerumbone (ZER) is sesquiterpene fro...
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| Format: | Article |
| Language: | English English |
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Science Publications
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17673/ http://psasir.upm.edu.my/id/eprint/17673/1/Zerumbone.pdf |
| _version_ | 1848843306738384896 |
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| author | Abdul, Ahmad Bustamam Abdelwahab, Siddig Ibrahim Al-Zubairi, Adel Sharaf Met, Mana Mohan, Syam Murali |
| author_facet | Abdul, Ahmad Bustamam Abdelwahab, Siddig Ibrahim Al-Zubairi, Adel Sharaf Met, Mana Mohan, Syam Murali |
| author_sort | Abdul, Ahmad Bustamam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Herbal drugs could be a new source for inhibitors of acetyl cholinesterase (anti-AChE), the key enzyme in the breakdown of acetylcholine and a new talented approach for the cure of elderly neurologically associated disorders such as Alzheimer's disease (AD). Zerumbone (ZER) is sesquiterpene from the edible plant, Zingiber zerumbet which is known to posses tremendous biological activities. In this study, the inhibitory effect of ZER towards acetyl cholinesterase was evaluated using thin layer chromatography (TLC bioautography and compared concurrently to tacrine, as positive control. The results obtained in this research showed that ZER has an enzymolytic effect towards AChE. It could be suggested that ZER might be a potential candidate for the development of anti-AD treatment. |
| first_indexed | 2025-11-15T08:12:56Z |
| format | Article |
| id | upm-17673 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:12:56Z |
| publishDate | 2008 |
| publisher | Science Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-176732015-12-07T06:44:41Z http://psasir.upm.edu.my/id/eprint/17673/ Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. Abdul, Ahmad Bustamam Abdelwahab, Siddig Ibrahim Al-Zubairi, Adel Sharaf Met, Mana Mohan, Syam Murali Herbal drugs could be a new source for inhibitors of acetyl cholinesterase (anti-AChE), the key enzyme in the breakdown of acetylcholine and a new talented approach for the cure of elderly neurologically associated disorders such as Alzheimer's disease (AD). Zerumbone (ZER) is sesquiterpene from the edible plant, Zingiber zerumbet which is known to posses tremendous biological activities. In this study, the inhibitory effect of ZER towards acetyl cholinesterase was evaluated using thin layer chromatography (TLC bioautography and compared concurrently to tacrine, as positive control. The results obtained in this research showed that ZER has an enzymolytic effect towards AChE. It could be suggested that ZER might be a potential candidate for the development of anti-AD treatment. Science Publications 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17673/1/Zerumbone.pdf Abdul, Ahmad Bustamam and Abdelwahab, Siddig Ibrahim and Al-Zubairi, Adel Sharaf and Met, Mana and Mohan, Syam Murali (2008) Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. American Journal of Pharmacology and Toxicology, 3 (3). pp. 209-211. ISSN 1557-4962 http://www.scipub.org/scipub/c4p.php?j_id=AJPT Zingiberaceae Alzheimer's disease - Prevention English |
| spellingShingle | Zingiberaceae Alzheimer's disease - Prevention Abdul, Ahmad Bustamam Abdelwahab, Siddig Ibrahim Al-Zubairi, Adel Sharaf Met, Mana Mohan, Syam Murali Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. |
| title | Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. |
| title_full | Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. |
| title_fullStr | Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. |
| title_full_unstemmed | Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. |
| title_short | Zerumbone : A Natural Compound with Anti-Cholinesterase Activity. |
| title_sort | zerumbone : a natural compound with anti-cholinesterase activity. |
| topic | Zingiberaceae Alzheimer's disease - Prevention |
| url | http://psasir.upm.edu.my/id/eprint/17673/ http://psasir.upm.edu.my/id/eprint/17673/ http://psasir.upm.edu.my/id/eprint/17673/1/Zerumbone.pdf |