The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats
The aim of this study is to determine the effects of Momordica charantia (MC) fruit aqueous extract on the liver histopathological changes in neonatal rats streptozotocin (STZ)-induced diabetes mellitus type II. Diabetes mellitus was induced in one day old neonatal Sprague-Dawley rats with STZ (85 m...
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| Format: | Article |
| Language: | English |
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Academic Journals
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17138/ http://psasir.upm.edu.my/id/eprint/17138/1/17138.pdf |
| _version_ | 1848843158869245952 |
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| author | Abdollahi, Maryam Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Rezaeizadeh, Alireza Mohamed Mustapha, Noordin |
| author_facet | Abdollahi, Maryam Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Rezaeizadeh, Alireza Mohamed Mustapha, Noordin |
| author_sort | Abdollahi, Maryam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The aim of this study is to determine the effects of Momordica charantia (MC) fruit aqueous extract on the liver histopathological changes in neonatal rats streptozotocin (STZ)-induced diabetes mellitus type II. Diabetes mellitus was induced in one day old neonatal Sprague-Dawley rats with STZ (85 mg/kg) and monitored for 12 weeks thereafter. The diabetic rats were separated into three groups as follows: the diabetic control group (nSTZ), the MC treated diabetic group (nSTZ/M), and the glibenclamide treated diabetic group (nSTZ/G). At the end of the treatment, blood glucose, serum insulin, alanine amino transferases (ALT) and aspartate amino transferases (AST) level was measured. Malondialdehyde (MDA) concentration was measured in the plasma and liver. The liver samples were processed for light microscopy examination. The results showed a reduction of blood glucose, ALT and AST, and increment of insulin level in the nSTZ/M and nSTZ/G rats. Administration of MC reduced the MDA concentration in plasma and liver of the nSTZ/M rats. Glucose tolerance and insulin sensitivity was improved in the nSTZ/M and nSTZ/G groups. The degenerative changes in liver were alleviated in the nSTZ/M and nSTZ/G groups. These results suggested that MC fruit aqueous extract may have a significant role in alleviating liver damage in the nSTZ-diabetic rats. |
| first_indexed | 2025-11-15T08:10:35Z |
| format | Article |
| id | upm-17138 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:10:35Z |
| publishDate | 2010 |
| publisher | Academic Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-171382016-11-18T09:02:39Z http://psasir.upm.edu.my/id/eprint/17138/ The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats Abdollahi, Maryam Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Rezaeizadeh, Alireza Mohamed Mustapha, Noordin The aim of this study is to determine the effects of Momordica charantia (MC) fruit aqueous extract on the liver histopathological changes in neonatal rats streptozotocin (STZ)-induced diabetes mellitus type II. Diabetes mellitus was induced in one day old neonatal Sprague-Dawley rats with STZ (85 mg/kg) and monitored for 12 weeks thereafter. The diabetic rats were separated into three groups as follows: the diabetic control group (nSTZ), the MC treated diabetic group (nSTZ/M), and the glibenclamide treated diabetic group (nSTZ/G). At the end of the treatment, blood glucose, serum insulin, alanine amino transferases (ALT) and aspartate amino transferases (AST) level was measured. Malondialdehyde (MDA) concentration was measured in the plasma and liver. The liver samples were processed for light microscopy examination. The results showed a reduction of blood glucose, ALT and AST, and increment of insulin level in the nSTZ/M and nSTZ/G rats. Administration of MC reduced the MDA concentration in plasma and liver of the nSTZ/M rats. Glucose tolerance and insulin sensitivity was improved in the nSTZ/M and nSTZ/G groups. The degenerative changes in liver were alleviated in the nSTZ/M and nSTZ/G groups. These results suggested that MC fruit aqueous extract may have a significant role in alleviating liver damage in the nSTZ-diabetic rats. Academic Journals 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17138/1/17138.pdf Abdollahi, Maryam and Abu Bakar @ Zakaria, Md Zuki and Goh, Yong Meng and Rezaeizadeh, Alireza and Mohamed Mustapha, Noordin (2010) The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats. African Journal of Biotechnology, 9 (31). art. no. 12043D124986. pp. 5004-5012. ISSN 1684–5315 http://www.academicjournals.org/journal/AJB/article-abstract/12043D124986 |
| spellingShingle | Abdollahi, Maryam Abu Bakar @ Zakaria, Md Zuki Goh, Yong Meng Rezaeizadeh, Alireza Mohamed Mustapha, Noordin The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| title | The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| title_full | The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| title_fullStr | The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| title_full_unstemmed | The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| title_short | The effects of Momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| title_sort | effects of momordica charantia on the liver in streptozotocin-induced diabetes in neonatal rats |
| url | http://psasir.upm.edu.my/id/eprint/17138/ http://psasir.upm.edu.my/id/eprint/17138/ http://psasir.upm.edu.my/id/eprint/17138/1/17138.pdf |