The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
This study was designed to determine whether zerumbone, an essential bioactive compound isolated from Zingiber zerumbet Smith protects against early ethanol induced liver injury in rats. Male Sprague-Dawley rats were administered with 0.05% (v/v) to 0.5% (v/v) of zerumbone for 14 days. Following the...
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| Format: | Article |
| Language: | English English |
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Asian Network for Scientific Information
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/17103/ http://psasir.upm.edu.my/id/eprint/17103/1/The%20effect%20of%20pretreatment%20of%20zerumbone%20on%20fatty%20liver%20following%20ethanol%20induced%20Hepatotoxicity.pdf |
| _version_ | 1848843148520849408 |
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| author | Fakurazi, Sharida Ithnin, Hairuszah Ganabadi, Shanti J., Mohd Lip |
| author_facet | Fakurazi, Sharida Ithnin, Hairuszah Ganabadi, Shanti J., Mohd Lip |
| author_sort | Fakurazi, Sharida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study was designed to determine whether zerumbone, an essential bioactive compound isolated from Zingiber zerumbet Smith protects against early ethanol induced liver injury in rats. Male Sprague-Dawley rats were administered with 0.05% (v/v) to 0.5% (v/v) of zerumbone for 14 days. Following the final dosage of zerumbone, the animals were administered with 50% (v/v) ethanol for 14 days. We have observed that pre-treatment of zerumbone had suppressed fatty liver formation following ethanol 50% (v/v) administration. Meanwhile, rats that were treated with ethanol only, found to show significant level of focal vacuolated fatty liver with focal necrosis in the mid zonal region. Therefore, fatty liver development was found to be extensively reduced in animals that were pretreated with zerumbone.
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| first_indexed | 2025-11-15T08:10:25Z |
| format | Article |
| id | upm-17103 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:10:25Z |
| publishDate | 2008 |
| publisher | Asian Network for Scientific Information |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-171032015-10-06T07:20:43Z http://psasir.upm.edu.my/id/eprint/17103/ The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity Fakurazi, Sharida Ithnin, Hairuszah Ganabadi, Shanti J., Mohd Lip This study was designed to determine whether zerumbone, an essential bioactive compound isolated from Zingiber zerumbet Smith protects against early ethanol induced liver injury in rats. Male Sprague-Dawley rats were administered with 0.05% (v/v) to 0.5% (v/v) of zerumbone for 14 days. Following the final dosage of zerumbone, the animals were administered with 50% (v/v) ethanol for 14 days. We have observed that pre-treatment of zerumbone had suppressed fatty liver formation following ethanol 50% (v/v) administration. Meanwhile, rats that were treated with ethanol only, found to show significant level of focal vacuolated fatty liver with focal necrosis in the mid zonal region. Therefore, fatty liver development was found to be extensively reduced in animals that were pretreated with zerumbone. Asian Network for Scientific Information 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17103/1/The%20effect%20of%20pretreatment%20of%20zerumbone%20on%20fatty%20liver%20following%20ethanol%20induced%20Hepatotoxicity.pdf Fakurazi, Sharida and Ithnin, Hairuszah and Ganabadi, Shanti and J., Mohd Lip (2008) The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity. Journal of Biological Sciences, 8 (8). pp. 1348-1351. ISSN 1727-3048, ESSN : 1812-5719 http://scialert.net/jindex.php?issn=1727-3048 Ginger - Therapeutic use. Medicinal plants. Fatty liver. English |
| spellingShingle | Ginger - Therapeutic use. Medicinal plants. Fatty liver. Fakurazi, Sharida Ithnin, Hairuszah Ganabadi, Shanti J., Mohd Lip The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity |
| title | The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
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| title_full | The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
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| title_fullStr | The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
|
| title_full_unstemmed | The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
|
| title_short | The effect of pretreatment of zerumbone on fatty liver following ethanol induced Hepatotoxicity
|
| title_sort | effect of pretreatment of zerumbone on fatty liver following ethanol induced hepatotoxicity |
| topic | Ginger - Therapeutic use. Medicinal plants. Fatty liver. |
| url | http://psasir.upm.edu.my/id/eprint/17103/ http://psasir.upm.edu.my/id/eprint/17103/ http://psasir.upm.edu.my/id/eprint/17103/1/The%20effect%20of%20pretreatment%20of%20zerumbone%20on%20fatty%20liver%20following%20ethanol%20induced%20Hepatotoxicity.pdf |