Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and cu...
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| Format: | Article |
| Language: | English English |
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Elsevier
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16920/ http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf |
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| author | Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin |
| author_facet | Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin |
| author_sort | Ka-Heng, Lee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and curcumin. However, these series of diarylpentanoidanalogues were not significantly inhibiting NO scavenging, total radical scavenging and tyrosinase enzyme activities. The results revealed that the biologicalactivity of these diarylpentanoidanalogues is most likely due to their action mainly upon inflammatory mediator, inducible nitric oxide synthase (iNOS). The present results showed that compounds 2, 13 and 33 might serve as a useful starting point for the design of improved anti-inflammatory agents. |
| first_indexed | 2025-11-15T08:09:36Z |
| format | Article |
| id | upm-16920 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:09:36Z |
| publishDate | 2009 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-169202015-09-28T00:56:48Z http://psasir.upm.edu.my/id/eprint/16920/ Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and curcumin. However, these series of diarylpentanoidanalogues were not significantly inhibiting NO scavenging, total radical scavenging and tyrosinase enzyme activities. The results revealed that the biologicalactivity of these diarylpentanoidanalogues is most likely due to their action mainly upon inflammatory mediator, inducible nitric oxide synthase (iNOS). The present results showed that compounds 2, 13 and 33 might serve as a useful starting point for the design of improved anti-inflammatory agents. Elsevier 2009-08 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf Ka-Heng, Lee and Ab. Aziz, Farida Haryani and Ahmad, Syahida and Abas, Faridah and Shaari, Khozirah and Israf Ali, Daud Ahmad and Lajis, Nordin (2009) Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. European Journal of Medicinal Chemistry, 44 (8). pp. 3195-3200. ISSN 0223-5234 Anti-inflammatory agents Antioxidants 10.1016/j.ejmech.2009.03.020 English |
| spellingShingle | Anti-inflammatory agents Antioxidants Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| title | Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| title_full | Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| title_fullStr | Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| title_full_unstemmed | Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| title_short | Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| title_sort | synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities |
| topic | Anti-inflammatory agents Antioxidants |
| url | http://psasir.upm.edu.my/id/eprint/16920/ http://psasir.upm.edu.my/id/eprint/16920/ http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf |