Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors

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Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors

A series of 16 oxadiazole and triazolothiadiazole derivatives were designed, synthesized and evaluated as mushroom tyrosinase inhibitors. Five derivatives were found to display high inhibition on the tyrosinase activity ranging from 0.87 to 1.49 lM. Compound 5 exhibited highest tyrosinase inhibitor...

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Bibliographic Details
Main Authors:	Lam, Kok Wai, Ahmad, Syahida, Ul-Haq, Zaheer, Abdul Rahman, Mohd Basyaruddin, Lajis, Nordin
Format:	Article
Language:	English
Published:	Elsevier 2010
Online Access:	http://psasir.upm.edu.my/id/eprint/16919/ http://psasir.upm.edu.my/id/eprint/16919/1/Synthesis%20and%20biological%20activity%20of%20oxadiazole%20and%20triazolothiadiazole%20derivatives%20as%20tyrosinase%20inhibitors.pdf

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