Preliminary analysis of the antinociceptive activity of zerumbone
We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16295/ |
| _version_ | 1848842921272410112 |
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| author | Sulaiman, Mohd Roslan Perimal, Enoch Kumar Zakaria, Zainul Amiruddin Mokhtar, Fuzi Akhtar, Muhammad Nadim Lajis, Md Nordin Israf Ali, Daud Ahmad |
| author_facet | Sulaiman, Mohd Roslan Perimal, Enoch Kumar Zakaria, Zainul Amiruddin Mokhtar, Fuzi Akhtar, Muhammad Nadim Lajis, Md Nordin Israf Ali, Daud Ahmad |
| author_sort | Sulaiman, Mohd Roslan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal
writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action. |
| first_indexed | 2025-11-15T08:06:49Z |
| format | Article |
| id | upm-16295 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:06:49Z |
| publishDate | 2009 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-162952013-03-29T08:33:21Z http://psasir.upm.edu.my/id/eprint/16295/ Preliminary analysis of the antinociceptive activity of zerumbone Sulaiman, Mohd Roslan Perimal, Enoch Kumar Zakaria, Zainul Amiruddin Mokhtar, Fuzi Akhtar, Muhammad Nadim Lajis, Md Nordin Israf Ali, Daud Ahmad We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action. Elsevier 2009-06 Article PeerReviewed Sulaiman, Mohd Roslan and Perimal, Enoch Kumar and Zakaria, Zainul Amiruddin and Mokhtar, Fuzi and Akhtar, Muhammad Nadim and Lajis, Md Nordin and Israf Ali, Daud Ahmad (2009) Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterapia, 80 (4). pp. 230-232. ISSN 0367-326X Analgesics Plant extracts Zingiberaceae 10.1016/j.fitote.2009.02.002 English |
| spellingShingle | Analgesics Plant extracts Zingiberaceae Sulaiman, Mohd Roslan Perimal, Enoch Kumar Zakaria, Zainul Amiruddin Mokhtar, Fuzi Akhtar, Muhammad Nadim Lajis, Md Nordin Israf Ali, Daud Ahmad Preliminary analysis of the antinociceptive activity of zerumbone |
| title | Preliminary analysis of the antinociceptive activity of zerumbone |
| title_full | Preliminary analysis of the antinociceptive activity of zerumbone |
| title_fullStr | Preliminary analysis of the antinociceptive activity of zerumbone |
| title_full_unstemmed | Preliminary analysis of the antinociceptive activity of zerumbone |
| title_short | Preliminary analysis of the antinociceptive activity of zerumbone |
| title_sort | preliminary analysis of the antinociceptive activity of zerumbone |
| topic | Analgesics Plant extracts Zingiberaceae |
| url | http://psasir.upm.edu.my/id/eprint/16295/ http://psasir.upm.edu.my/id/eprint/16295/ |