PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CAIX and VEGF, in human cancer cell lines.

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PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CAIX and VEGF, in human cancer cell lines.

The phosphatidylinositol 3-kinase/Akt (PI3K) pathway regulates hypoxia-inducible factor (HIF) activity. Higher expression of HIF-1α and carbonic anhydrase IX (CAIX), a hypoxia-inducible gene, in HT10806TG fibrosarcoma cells (mutant N-ras allele), compared to derivative MCH603 cells (deleted mutant N...

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Bibliographic Details
Main Authors:	Shafee, Norazizah, Kaluz, Stefan, Ru, Ning, Stanbridge, Eric John
Format:	Article
Language:	English
Published:	Elsevier 2009
Online Access:	http://psasir.upm.edu.my/id/eprint/16221/

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