Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases
T cells undergo a series of complex phenotypic changes before achieving maturation. Discrete stages of T-cell differentiation are simplified to four stages (pro-, pre-, cortical and mature-T cell) and used in the classification of T-cell leukaemia. HLA-DR has been reported to be expressed in immatur...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Maney Publishing
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16179/ http://psasir.upm.edu.my/id/eprint/16179/1/Phenotype%20and%20TCR.pdf |
| _version_ | 1848842887354122240 |
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| author | Abdullah, Maha Gan, Gin Gin Koh, Chong Lek |
| author_facet | Abdullah, Maha Gan, Gin Gin Koh, Chong Lek |
| author_sort | Abdullah, Maha |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | T cells undergo a series of complex phenotypic changes before achieving maturation. Discrete stages of T-cell differentiation are simplified to four stages (pro-, pre-, cortical and mature-T cell) and used in the classification of T-cell leukaemia. HLA-DR has been reported to be expressed in immature T-cell acute lymphoblastic leukemia (ALL) and also confer a poorer treatment outcome. Simultaneously, the genotype goes through distinct pattern changes due to rearrangement of T-cell receptor (TCR) genes. TCR gene rearrangement is important in the diagnosis of clonality and used as markers to detect minimal residual disease in lymphoproliferative disorders. We identified a subset within Pro-T and Pre-T cell cases distinguished by the expression of HLA-DR. These subgroups appeared to be more immature as rearrangement of the TCR-gamma gene was either at germline or involved only the first constant region (C1) unlike a more rearranged pattern in the HLA-DR-subgroups. We also observed a higher incidence of mediastinal mass (67%) in the HLA-DR-subgroup in the Pre-T stage. These characteristics may be useful as markers to further refine staging of T-cell ALL and determine prognosis. |
| first_indexed | 2025-11-15T08:06:16Z |
| format | Article |
| id | upm-16179 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:06:16Z |
| publishDate | 2010 |
| publisher | Maney Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-161792016-02-03T06:33:45Z http://psasir.upm.edu.my/id/eprint/16179/ Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases Abdullah, Maha Gan, Gin Gin Koh, Chong Lek T cells undergo a series of complex phenotypic changes before achieving maturation. Discrete stages of T-cell differentiation are simplified to four stages (pro-, pre-, cortical and mature-T cell) and used in the classification of T-cell leukaemia. HLA-DR has been reported to be expressed in immature T-cell acute lymphoblastic leukemia (ALL) and also confer a poorer treatment outcome. Simultaneously, the genotype goes through distinct pattern changes due to rearrangement of T-cell receptor (TCR) genes. TCR gene rearrangement is important in the diagnosis of clonality and used as markers to detect minimal residual disease in lymphoproliferative disorders. We identified a subset within Pro-T and Pre-T cell cases distinguished by the expression of HLA-DR. These subgroups appeared to be more immature as rearrangement of the TCR-gamma gene was either at germline or involved only the first constant region (C1) unlike a more rearranged pattern in the HLA-DR-subgroups. We also observed a higher incidence of mediastinal mass (67%) in the HLA-DR-subgroup in the Pre-T stage. These characteristics may be useful as markers to further refine staging of T-cell ALL and determine prognosis. Maney Publishing 2010-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16179/1/Phenotype%20and%20TCR.pdf Abdullah, Maha and Gan, Gin Gin and Koh, Chong Lek (2010) Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases. Hematology, 15 (6). pp. 382-390. ISSN 1024-5332, ESSN: 1607-8454 http://dx.doi.org/10.1179/102453310X12719010991902 Leukemia - T-Cell 10.1179/102453310X12719010991902 |
| spellingShingle | Leukemia - T-Cell Abdullah, Maha Gan, Gin Gin Koh, Chong Lek Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases |
| title | Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases |
| title_full | Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases |
| title_fullStr | Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases |
| title_full_unstemmed | Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases |
| title_short | Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases |
| title_sort | phenotype and tcr-gamma gene rearrangements in a malaysian cohort of t-cell leukaemia/lymphoma cases |
| topic | Leukemia - T-Cell |
| url | http://psasir.upm.edu.my/id/eprint/16179/ http://psasir.upm.edu.my/id/eprint/16179/ http://psasir.upm.edu.my/id/eprint/16179/ http://psasir.upm.edu.my/id/eprint/16179/1/Phenotype%20and%20TCR.pdf |