Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma.
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a systemic disease involving nodal and extranodal tissues. We report a 48-year-old female with recurrent nasal obstruction due to polypoidal masses involving the nasal sinuses, turbinates and septu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Malaysian Society of Pathologists
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15747/ http://psasir.upm.edu.my/id/eprint/15747/1/Multifocal%20nodal%20and%20extranodal%20Rosai.pdf |
| _version_ | 1848842765114277888 |
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| author | Mohd Sidik, Shiran Tan, Geok Chin M. Solahuddin, Kenali Abdul Rahman, Sabariah Rajadurai, Pathmanathan |
| author_facet | Mohd Sidik, Shiran Tan, Geok Chin M. Solahuddin, Kenali Abdul Rahman, Sabariah Rajadurai, Pathmanathan |
| author_sort | Mohd Sidik, Shiran |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a systemic disease involving nodal and extranodal tissues. We report a 48-year-old female with recurrent nasal obstruction due to polypoidal masses involving the nasal sinuses, turbinates and septum bilaterally, and lumps in the right infra-orbital region and region of the right lacrimal sac. A 4 cm right upper neck mass was also noted, which was initially diagnosed as histiocytic lymphoma. Histopathology of the nasal and infraorbital lesions revealed fibro-inflammatory masses containing histiocytic cells with large vesicular nuclei and abundant foamy cytoplasm exhibiting emperipolesis and lymphophagocytosis, admixed with scattered plasma cells and lymphocytes. These histiocytes revealed immunohistochemical positivity for S-100 protein and CD68, but were negative for CDla. The findings supported a diagnosis of RDD. This report serves to remind pathologists and clinicians of the extranodal manifestations of RDD and its potential confusion with lymphomas. |
| first_indexed | 2025-11-15T08:04:20Z |
| format | Article |
| id | upm-15747 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:04:20Z |
| publishDate | 2008 |
| publisher | Malaysian Society of Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-157472015-10-23T06:50:00Z http://psasir.upm.edu.my/id/eprint/15747/ Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. Mohd Sidik, Shiran Tan, Geok Chin M. Solahuddin, Kenali Abdul Rahman, Sabariah Rajadurai, Pathmanathan Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a systemic disease involving nodal and extranodal tissues. We report a 48-year-old female with recurrent nasal obstruction due to polypoidal masses involving the nasal sinuses, turbinates and septum bilaterally, and lumps in the right infra-orbital region and region of the right lacrimal sac. A 4 cm right upper neck mass was also noted, which was initially diagnosed as histiocytic lymphoma. Histopathology of the nasal and infraorbital lesions revealed fibro-inflammatory masses containing histiocytic cells with large vesicular nuclei and abundant foamy cytoplasm exhibiting emperipolesis and lymphophagocytosis, admixed with scattered plasma cells and lymphocytes. These histiocytes revealed immunohistochemical positivity for S-100 protein and CD68, but were negative for CDla. The findings supported a diagnosis of RDD. This report serves to remind pathologists and clinicians of the extranodal manifestations of RDD and its potential confusion with lymphomas. Malaysian Society of Pathologists 2008-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15747/1/Multifocal%20nodal%20and%20extranodal%20Rosai.pdf Mohd Sidik, Shiran and Tan, Geok Chin and M. Solahuddin, Kenali and Abdul Rahman, Sabariah and Rajadurai, Pathmanathan (2008) Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. Malaysian Journal of Pathology, 30 (1). pp. 63-65. ISSN 0126-8635 English |
| spellingShingle | Mohd Sidik, Shiran Tan, Geok Chin M. Solahuddin, Kenali Abdul Rahman, Sabariah Rajadurai, Pathmanathan Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. |
| title | Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. |
| title_full | Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. |
| title_fullStr | Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. |
| title_full_unstemmed | Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. |
| title_short | Multifocal nodal and extranodal Rosai-Dorfman disease initially diagnosed as histiocytic lymphoma. |
| title_sort | multifocal nodal and extranodal rosai-dorfman disease initially diagnosed as histiocytic lymphoma. |
| url | http://psasir.upm.edu.my/id/eprint/15747/ http://psasir.upm.edu.my/id/eprint/15747/1/Multifocal%20nodal%20and%20extranodal%20Rosai.pdf |