In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibit...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Karger: Open Access Journals
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15172/ http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf |
| _version_ | 1848842602466508800 |
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| author | Khalid, Syamimi Shaik Mossadeq, Wan Mastura Daud , Ahmad Israf Hashim, Puziah Rejab, S. Shaberi, A.M. Mohamad, Azam Shah Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan |
| author_facet | Khalid, Syamimi Shaik Mossadeq, Wan Mastura Daud , Ahmad Israf Hashim, Puziah Rejab, S. Shaberi, A.M. Mohamad, Azam Shah Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan |
| author_sort | Khalid, Syamimi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism. |
| first_indexed | 2025-11-15T08:01:44Z |
| format | Article |
| id | upm-15172 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:01:44Z |
| publishDate | 2010 |
| publisher | Karger: Open Access Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-151722015-09-22T07:41:56Z http://psasir.upm.edu.my/id/eprint/15172/ In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Khalid, Syamimi Shaik Mossadeq, Wan Mastura Daud , Ahmad Israf Hashim, Puziah Rejab, S. Shaberi, A.M. Mohamad, Azam Shah Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism. Karger: Open Access Journals 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf Khalid, Syamimi and Shaik Mossadeq, Wan Mastura and Daud , Ahmad Israf and Hashim, Puziah and Rejab, S. and Shaberi, A.M. and Mohamad, Azam Shah and Zakaria, Zainul Amiruddin and Sulaiman, Mohd Roslan (2010) In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Medical Principles and Practice, 19 (4). pp. 255-259. ISSN 1011-7571; ESSN:1423-0151 10.1159/000312710 English |
| spellingShingle | Khalid, Syamimi Shaik Mossadeq, Wan Mastura Daud , Ahmad Israf Hashim, Puziah Rejab, S. Shaberi, A.M. Mohamad, Azam Shah Zakaria, Zainul Amiruddin Sulaiman, Mohd Roslan In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. |
| title | In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. |
| title_full | In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. |
| title_fullStr | In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. |
| title_full_unstemmed | In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. |
| title_short | In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. |
| title_sort | in vivo analgesic effect of aqueous extract of tamarindus indica l. fruits. |
| url | http://psasir.upm.edu.my/id/eprint/15172/ http://psasir.upm.edu.my/id/eprint/15172/ http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf |