Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis
A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor bind...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15079/ http://psasir.upm.edu.my/id/eprint/15079/1/Identification%20of%20possible%20compounds%20possessing%20adenosine%20A1%20receptor%20binding%20activity%20in%20the%20leaves%20of%20orthosiphon%20stamineus%20using%20TLC%20and%20multivariate%20data%20analysis.pdf |
| _version_ | 1848842576351723520 |
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| author | Khatib, Alfi Nancy Dewi Yuliana, Selamat, Jinap Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Chung, Shin Kyo Verpoorte, Robert |
| author_facet | Khatib, Alfi Nancy Dewi Yuliana, Selamat, Jinap Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Chung, Shin Kyo Verpoorte, Robert |
| author_sort | Khatib, Alfi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxyflavonoids, fatty acids or terpenoids were estimated to be related to this activity. The results of this study support the traditional use in Indonesia of O. stamineus as a functional drink to treat kidney stones. |
| first_indexed | 2025-11-15T08:01:20Z |
| format | Article |
| id | upm-15079 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:01:20Z |
| publishDate | 2009 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-150792015-09-28T01:52:25Z http://psasir.upm.edu.my/id/eprint/15079/ Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis Khatib, Alfi Nancy Dewi Yuliana, Selamat, Jinap Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Chung, Shin Kyo Verpoorte, Robert A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of O. stamineus was developed. O. stamineus extract is one of the components of a functional beverage used in Indonesia for the treatment of kidney stones. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxyflavonoids, fatty acids or terpenoids were estimated to be related to this activity. The results of this study support the traditional use in Indonesia of O. stamineus as a functional drink to treat kidney stones. Taylor & Francis 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/15079/1/Identification%20of%20possible%20compounds%20possessing%20adenosine%20A1%20receptor%20binding%20activity%20in%20the%20leaves%20of%20orthosiphon%20stamineus%20using%20TLC%20and%20multivariate%20data%20analysis.pdf Khatib, Alfi and Nancy Dewi Yuliana, and Selamat, Jinap and Sarker, Md. Zaidul Islam and Jaswir, Irwandi and Wilson, Erica G. and Chung, Shin Kyo and Verpoorte, Robert (2009) Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis. Journal of Liquid Chromatography & Related Technologies, 32 (19). pp. 2906-2916. ISSN 1082-6076; ESSN: 1520-572X 10.1080/10826070903297459 |
| spellingShingle | Khatib, Alfi Nancy Dewi Yuliana, Selamat, Jinap Sarker, Md. Zaidul Islam Jaswir, Irwandi Wilson, Erica G. Chung, Shin Kyo Verpoorte, Robert Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title | Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title_full | Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title_fullStr | Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title_full_unstemmed | Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title_short | Identification of possible compounds possessing adenosine A1 receptor binding activity in the leaves of orthosiphon stamineus using TLC and multivariate data analysis |
| title_sort | identification of possible compounds possessing adenosine a1 receptor binding activity in the leaves of orthosiphon stamineus using tlc and multivariate data analysis |
| url | http://psasir.upm.edu.my/id/eprint/15079/ http://psasir.upm.edu.my/id/eprint/15079/ http://psasir.upm.edu.my/id/eprint/15079/1/Identification%20of%20possible%20compounds%20possessing%20adenosine%20A1%20receptor%20binding%20activity%20in%20the%20leaves%20of%20orthosiphon%20stamineus%20using%20TLC%20and%20multivariate%20data%20analysis.pdf |