Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation.
The ultra-structure of Mycobacterium tuberculosis (MTB) was examined by transmission electronic (TEM)) and atomic force microscopy (AFM). The study was performed to describe the morphology of susceptible, multidrug-resistant (MDR), extensively drug-resistant (XDR) and extremely drug-resistant tuberc...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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e-Century Publishing Corporation
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14923/ http://psasir.upm.edu.my/id/eprint/14923/1/Growth%20and%20cell.pdf |
| _version_ | 1848842533918998528 |
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| author | Farnia, Parissa Masjedi, Mohammad Reza Merza, Muayad Aghali Tabarsi, Payam Zhavnerko, Gennady Konstantinovich Tengku Ibrahim, Tengku Azmi Kuan, Ho O. Ghanavei, Jalladein Ranjbar, Reza Poleschuyk, Nikolai Nikolaevich Titov, Leonid Petrovich Owlia, Parviz Kazampour, Mehadi Setareh, Mohammad Sheikolslami, Muaryam Migliori, Giovanni Battista Velayati, Ali Akbar |
| author_facet | Farnia, Parissa Masjedi, Mohammad Reza Merza, Muayad Aghali Tabarsi, Payam Zhavnerko, Gennady Konstantinovich Tengku Ibrahim, Tengku Azmi Kuan, Ho O. Ghanavei, Jalladein Ranjbar, Reza Poleschuyk, Nikolai Nikolaevich Titov, Leonid Petrovich Owlia, Parviz Kazampour, Mehadi Setareh, Mohammad Sheikolslami, Muaryam Migliori, Giovanni Battista Velayati, Ali Akbar |
| author_sort | Farnia, Parissa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The ultra-structure of Mycobacterium tuberculosis (MTB) was examined by transmission electronic (TEM)) and atomic force microscopy (AFM). The study was performed to describe the morphology of susceptible, multidrug-resistant (MDR), extensively drug-resistant (XDR) and extremely drug-resistant tuberculosis isolates (XXDR-TB) during their exponential growth phase. Four types of cell division were observed and described. While three of them (symmetrical, asymmetrical and branching type) occurred in all isolates studied, the fourth one (adapted type) was seen only in XDR and XXDR-TB bacilli. In the fourth type of cell division, a rod shaped mother cell produced a small round shape bacillus (0.3-0.5 μm). These round cells were different from buds or polar division, but similar to terminal endospores without showing the typing heat resistance. Based on the present observation, we suggest that XDR-and XXDR-TB bacilli accommodate changes helping them to overcome the hostile environment. Viewed under AFM, the other frequently detected shapes in MTB isolates were oval, V, Y and multi-branching filaments. These shape variation confirmed pleomorphic phenomena in MTB populations and the specific features of pan-resistant strains |
| first_indexed | 2025-11-15T08:00:39Z |
| format | Article |
| id | upm-14923 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:00:39Z |
| publishDate | 2010 |
| publisher | e-Century Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-149232015-09-28T01:59:30Z http://psasir.upm.edu.my/id/eprint/14923/ Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. Farnia, Parissa Masjedi, Mohammad Reza Merza, Muayad Aghali Tabarsi, Payam Zhavnerko, Gennady Konstantinovich Tengku Ibrahim, Tengku Azmi Kuan, Ho O. Ghanavei, Jalladein Ranjbar, Reza Poleschuyk, Nikolai Nikolaevich Titov, Leonid Petrovich Owlia, Parviz Kazampour, Mehadi Setareh, Mohammad Sheikolslami, Muaryam Migliori, Giovanni Battista Velayati, Ali Akbar The ultra-structure of Mycobacterium tuberculosis (MTB) was examined by transmission electronic (TEM)) and atomic force microscopy (AFM). The study was performed to describe the morphology of susceptible, multidrug-resistant (MDR), extensively drug-resistant (XDR) and extremely drug-resistant tuberculosis isolates (XXDR-TB) during their exponential growth phase. Four types of cell division were observed and described. While three of them (symmetrical, asymmetrical and branching type) occurred in all isolates studied, the fourth one (adapted type) was seen only in XDR and XXDR-TB bacilli. In the fourth type of cell division, a rod shaped mother cell produced a small round shape bacillus (0.3-0.5 μm). These round cells were different from buds or polar division, but similar to terminal endospores without showing the typing heat resistance. Based on the present observation, we suggest that XDR-and XXDR-TB bacilli accommodate changes helping them to overcome the hostile environment. Viewed under AFM, the other frequently detected shapes in MTB isolates were oval, V, Y and multi-branching filaments. These shape variation confirmed pleomorphic phenomena in MTB populations and the specific features of pan-resistant strains e-Century Publishing Corporation 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14923/1/Growth%20and%20cell.pdf Farnia, Parissa and Masjedi, Mohammad Reza and Merza, Muayad Aghali and Tabarsi, Payam and Zhavnerko, Gennady Konstantinovich and Tengku Ibrahim, Tengku Azmi and Kuan, Ho O. and Ghanavei, Jalladein and Ranjbar, Reza and Poleschuyk, Nikolai Nikolaevich and Titov, Leonid Petrovich and Owlia, Parviz and Kazampour, Mehadi and Setareh, Mohammad and Sheikolslami, Muaryam and Migliori, Giovanni Battista and Velayati, Ali Akbar (2010) Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. International Journal of Clinical and Experimental Medicine, 3 (4). pp. 308-314. ISSN 1940-5901 English |
| spellingShingle | Farnia, Parissa Masjedi, Mohammad Reza Merza, Muayad Aghali Tabarsi, Payam Zhavnerko, Gennady Konstantinovich Tengku Ibrahim, Tengku Azmi Kuan, Ho O. Ghanavei, Jalladein Ranjbar, Reza Poleschuyk, Nikolai Nikolaevich Titov, Leonid Petrovich Owlia, Parviz Kazampour, Mehadi Setareh, Mohammad Sheikolslami, Muaryam Migliori, Giovanni Battista Velayati, Ali Akbar Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. |
| title | Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. |
| title_full | Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. |
| title_fullStr | Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. |
| title_full_unstemmed | Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. |
| title_short | Growth and cell-division in extensive (XDR) and extremely drug resistant (XXDR) tuberculosis strains: transmission and atomic force observation. |
| title_sort | growth and cell-division in extensive (xdr) and extremely drug resistant (xxdr) tuberculosis strains: transmission and atomic force observation. |
| url | http://psasir.upm.edu.my/id/eprint/14923/ http://psasir.upm.edu.my/id/eprint/14923/1/Growth%20and%20cell.pdf |