Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis.
Burkholderia pseudomallei is the causative agent of melioidosis, a serious disease of man and animals. The high mortality of B. pseudomallei infections may cause by Lipopolysaccharides (LPS), an endotoxin. The biosynthesis of LPS is complex comprising three components, lipid A, core oligosaccharide...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Medwell Journals
2009
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/14864/ http://psasir.upm.edu.my/id/eprint/14864/1/Genes%20expression%20in%20biosynthesis%20Lipopolysaccharide%20of%20Burkholderia%20pseudomallei%20the%20causative%20agent%20of%20melioidosis.pdf |
| _version_ | 1848842516256784384 |
|---|---|
| author | Abdullah Al-Haj, Nagi Ahmed Lai, L. Suang Shamsudin, Mariana Nor Abdullah, Rasedee Mohamed, Rahmah Sekawi, Zamberi |
| author_facet | Abdullah Al-Haj, Nagi Ahmed Lai, L. Suang Shamsudin, Mariana Nor Abdullah, Rasedee Mohamed, Rahmah Sekawi, Zamberi |
| author_sort | Abdullah Al-Haj, Nagi Ahmed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Burkholderia pseudomallei is the causative agent of melioidosis, a serious disease of man and animals. The high mortality of B. pseudomallei infections may cause by Lipopolysaccharides (LPS), an endotoxin. The biosynthesis of LPS is complex comprising three components, lipid A, core oligosaccharide and O-specific antigen. In the current study was designed to further elucidate genes involved in the biosynthesis pathway of LPS in melioidosis agent followed with selected gene product expression with essential function for survival and virulence melioidosis agent. Expression of Bplps0013/lpxA and Bplps0007/rfaF successful expressed the entire proteins in 2 h with sizes of approximately 29 kDa and 43.7 kDa, respectively. The baseline information provided through the present research can be a preliminary approach towards the development of effective therapeutics against melioidosis. |
| first_indexed | 2025-11-15T08:00:22Z |
| format | Article |
| id | upm-14864 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:00:22Z |
| publishDate | 2009 |
| publisher | Medwell Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-148642015-11-24T03:14:12Z http://psasir.upm.edu.my/id/eprint/14864/ Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. Abdullah Al-Haj, Nagi Ahmed Lai, L. Suang Shamsudin, Mariana Nor Abdullah, Rasedee Mohamed, Rahmah Sekawi, Zamberi Burkholderia pseudomallei is the causative agent of melioidosis, a serious disease of man and animals. The high mortality of B. pseudomallei infections may cause by Lipopolysaccharides (LPS), an endotoxin. The biosynthesis of LPS is complex comprising three components, lipid A, core oligosaccharide and O-specific antigen. In the current study was designed to further elucidate genes involved in the biosynthesis pathway of LPS in melioidosis agent followed with selected gene product expression with essential function for survival and virulence melioidosis agent. Expression of Bplps0013/lpxA and Bplps0007/rfaF successful expressed the entire proteins in 2 h with sizes of approximately 29 kDa and 43.7 kDa, respectively. The baseline information provided through the present research can be a preliminary approach towards the development of effective therapeutics against melioidosis. Medwell Journals 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14864/1/Genes%20expression%20in%20biosynthesis%20Lipopolysaccharide%20of%20Burkholderia%20pseudomallei%20the%20causative%20agent%20of%20melioidosis.pdf Abdullah Al-Haj, Nagi Ahmed and Lai, L. Suang and Shamsudin, Mariana Nor and Abdullah, Rasedee and Mohamed, Rahmah and Sekawi, Zamberi (2009) Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. Research Journal of Biological Sciences, 4 (6). pp. 668-674. ISSN 1815-8846; ESSN: 1993-6087 http://www.medwelljournals.com English |
| spellingShingle | Abdullah Al-Haj, Nagi Ahmed Lai, L. Suang Shamsudin, Mariana Nor Abdullah, Rasedee Mohamed, Rahmah Sekawi, Zamberi Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. |
| title | Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. |
| title_full | Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. |
| title_fullStr | Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. |
| title_full_unstemmed | Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. |
| title_short | Genes expression in biosynthesis Lipopolysaccharide of Burkholderia pseudomallei the causative agent of melioidosis. |
| title_sort | genes expression in biosynthesis lipopolysaccharide of burkholderia pseudomallei the causative agent of melioidosis. |
| url | http://psasir.upm.edu.my/id/eprint/14864/ http://psasir.upm.edu.my/id/eprint/14864/ http://psasir.upm.edu.my/id/eprint/14864/1/Genes%20expression%20in%20biosynthesis%20Lipopolysaccharide%20of%20Burkholderia%20pseudomallei%20the%20causative%20agent%20of%20melioidosis.pdf |