Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C
Ardisia crispa Thunb D.C (Myrsinaceae), has long been used in treating various ailments among the local villagers. The objective of this study was to investigate experimentally the possible anti-ulcer activity of Ardisia crispa. The effect of hexane fraction of root of Ardisia crispa (ACRH) was eval...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer - Medknow Publications
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14594/ http://psasir.upm.edu.my/id/eprint/14594/1/Evaluation%20of%20anti.pdf |
| _version_ | 1848842437511872512 |
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| author | Abd Hamid @ Abdul Razak, Roslida Teh, Y. H. Kim, Kah Hwi |
| author_facet | Abd Hamid @ Abdul Razak, Roslida Teh, Y. H. Kim, Kah Hwi |
| author_sort | Abd Hamid @ Abdul Razak, Roslida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Ardisia crispa Thunb D.C (Myrsinaceae), has long been used in treating various ailments among the local villagers. The objective of this study was to investigate experimentally the possible anti-ulcer activity of Ardisia crispa. The effect of hexane fraction of root of Ardisia crispa (ACRH) was evaluated in experimental ulcer models with necrotizing agents ie ethanol, NaCl, HCl, NaOH and also COX-1 inhibitor namely indomethacin as inducers. Four doses ie 10, 30, 100 and 300 mg/kg were selected for further study. Ulcer effects were determined by counting the total surface area of lesion in mm 2 . Results showed that ACRH provided significant protection in various experimental models used. Pretreatment with ACRH at all doses (10,30,100 and 300 mg/kg) has produced significant inhibition of gastric mucosal damage induced by 80% EtOH and 25% NaCl, whilst at 30, 100 and 300 mg/ kg, ACRH significantly reduced the lesion formation in ulcer induced by 0.6 M HCl, 0.2 M NaOH and 30 mg/kg indomethacin. The present study indicates that the hexane fraction of Ardisia crispa (ACRH) exhibits significant anti-ulcer effect. |
| first_indexed | 2025-11-15T07:59:07Z |
| format | Article |
| id | upm-14594 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:59:07Z |
| publishDate | 2009 |
| publisher | Wolters Kluwer - Medknow Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-145942016-10-28T04:26:13Z http://psasir.upm.edu.my/id/eprint/14594/ Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C Abd Hamid @ Abdul Razak, Roslida Teh, Y. H. Kim, Kah Hwi Ardisia crispa Thunb D.C (Myrsinaceae), has long been used in treating various ailments among the local villagers. The objective of this study was to investigate experimentally the possible anti-ulcer activity of Ardisia crispa. The effect of hexane fraction of root of Ardisia crispa (ACRH) was evaluated in experimental ulcer models with necrotizing agents ie ethanol, NaCl, HCl, NaOH and also COX-1 inhibitor namely indomethacin as inducers. Four doses ie 10, 30, 100 and 300 mg/kg were selected for further study. Ulcer effects were determined by counting the total surface area of lesion in mm 2 . Results showed that ACRH provided significant protection in various experimental models used. Pretreatment with ACRH at all doses (10,30,100 and 300 mg/kg) has produced significant inhibition of gastric mucosal damage induced by 80% EtOH and 25% NaCl, whilst at 30, 100 and 300 mg/ kg, ACRH significantly reduced the lesion formation in ulcer induced by 0.6 M HCl, 0.2 M NaOH and 30 mg/kg indomethacin. The present study indicates that the hexane fraction of Ardisia crispa (ACRH) exhibits significant anti-ulcer effect. Wolters Kluwer - Medknow Publications 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14594/1/Evaluation%20of%20anti.pdf Abd Hamid @ Abdul Razak, Roslida and Teh, Y. H. and Kim, Kah Hwi (2009) Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C. Pharmacognosy Research, 1 (5). pp. 250-255. ISSN 0976-4836; ESSN: 0974-8490 http://phcogres.com/article.asp?issn=0974-8490;year=2009;volume=1;issue=5;spage=250;epage=255;aulast=Roslida;type=0 |
| spellingShingle | Abd Hamid @ Abdul Razak, Roslida Teh, Y. H. Kim, Kah Hwi Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C |
| title | Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C |
| title_full | Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C |
| title_fullStr | Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C |
| title_full_unstemmed | Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C |
| title_short | Evaluation of anti-ulcer activity of Ardisia crispa Thunb. D.C |
| title_sort | evaluation of anti-ulcer activity of ardisia crispa thunb. d.c |
| url | http://psasir.upm.edu.my/id/eprint/14594/ http://psasir.upm.edu.my/id/eprint/14594/ http://psasir.upm.edu.my/id/eprint/14594/1/Evaluation%20of%20anti.pdf |