Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus
This study investigated the antibacterial activity of the methanolic extract of the animal to justify its use in traditional medicine. Antimicrobial activity was assayed by disc diffusion method and broth macro dilution method. From the result it appeared that the methanolic extract of Stichopus bad...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian Network for Scientific Information
2009
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/14585/ http://psasir.upm.edu.my/id/eprint/14585/1/Evaluating%20the%20antibacterial%20activity%20and%20in%20vivo%20assay%20of%20methanolic%20extract%20of%20Stichopus%20badionotus.pdf |
| _version_ | 1848842434957541376 |
|---|---|
| author | Shamsudin, Mariana Nor Mohamed Alipiah, Norfarrah Nik Ibrahim, Nik Khairul Azizi Md. Yusoff, Fatimah Arshad, Aziz |
| author_facet | Shamsudin, Mariana Nor Mohamed Alipiah, Norfarrah Nik Ibrahim, Nik Khairul Azizi Md. Yusoff, Fatimah Arshad, Aziz |
| author_sort | Shamsudin, Mariana Nor |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study investigated the antibacterial activity of the methanolic extract of the animal to justify its use in traditional medicine. Antimicrobial activity was assayed by disc diffusion method and broth macro dilution method. From the result it appeared that the methanolic extract of Stichopus badionotus displayed antibacterial activities against Staphylococcus aureus, three non resistant strains and three multiple resistant strains. The Minimum Inhibitory Concentration (MIC) of the extract against non resistant strain values were 3.75 mg mL-1 and for resistant strain values 7.50 mg mL-1. Further more, this extract tested on rats in wound infection model justified faster healing rates compared to antibiotics. These results indicate that the traditional use of these holothurians for the treatment of S. aureus infection mainly on resistant strains should be elucidate to bring out the potential antibacterial agent. |
| first_indexed | 2025-11-15T07:59:05Z |
| format | Article |
| id | upm-14585 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:59:05Z |
| publishDate | 2009 |
| publisher | Asian Network for Scientific Information |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-145852017-01-10T09:35:36Z http://psasir.upm.edu.my/id/eprint/14585/ Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus Shamsudin, Mariana Nor Mohamed Alipiah, Norfarrah Nik Ibrahim, Nik Khairul Azizi Md. Yusoff, Fatimah Arshad, Aziz This study investigated the antibacterial activity of the methanolic extract of the animal to justify its use in traditional medicine. Antimicrobial activity was assayed by disc diffusion method and broth macro dilution method. From the result it appeared that the methanolic extract of Stichopus badionotus displayed antibacterial activities against Staphylococcus aureus, three non resistant strains and three multiple resistant strains. The Minimum Inhibitory Concentration (MIC) of the extract against non resistant strain values were 3.75 mg mL-1 and for resistant strain values 7.50 mg mL-1. Further more, this extract tested on rats in wound infection model justified faster healing rates compared to antibiotics. These results indicate that the traditional use of these holothurians for the treatment of S. aureus infection mainly on resistant strains should be elucidate to bring out the potential antibacterial agent. Asian Network for Scientific Information 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14585/1/Evaluating%20the%20antibacterial%20activity%20and%20in%20vivo%20assay%20of%20methanolic%20extract%20of%20Stichopus%20badionotus.pdf Shamsudin, Mariana Nor and Mohamed Alipiah, Norfarrah and Nik Ibrahim, Nik Khairul Azizi and Md. Yusoff, Fatimah and Arshad, Aziz (2009) Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus. International Journal of Pharmacology, 5 (3). pp. 228-231. ISSN 1811-7775; ESSN: 1812-5700 http://www.scialert.net/abstract/?doi=ijp.2009.228.231 10.3923/ijp.2009.228.231 |
| spellingShingle | Shamsudin, Mariana Nor Mohamed Alipiah, Norfarrah Nik Ibrahim, Nik Khairul Azizi Md. Yusoff, Fatimah Arshad, Aziz Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus |
| title | Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus |
| title_full | Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus |
| title_fullStr | Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus |
| title_full_unstemmed | Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus |
| title_short | Evaluating the antibacterial activity and in vivo assay of methanolic extract of Stichopus badionotus |
| title_sort | evaluating the antibacterial activity and in vivo assay of methanolic extract of stichopus badionotus |
| url | http://psasir.upm.edu.my/id/eprint/14585/ http://psasir.upm.edu.my/id/eprint/14585/ http://psasir.upm.edu.my/id/eprint/14585/ http://psasir.upm.edu.my/id/eprint/14585/1/Evaluating%20the%20antibacterial%20activity%20and%20in%20vivo%20assay%20of%20methanolic%20extract%20of%20Stichopus%20badionotus.pdf |