Enzymatic synthesis of betulinic acid ester as an anticancer agent: optimization study

QR Code

Enzymatic synthesis of betulinic acid ester as an anticancer agent: optimization study

Immobilized Candida antarctica lipase, Novozym 435, was used to catalyze the esterification reaction between betulinic acid and phthalic anhydride to synthesize 3-O-phthalyl betulinic acid in n-hexane/chloroform. Response surface methodology based on a five-level, four-variable central composite rot...

Full description

Bibliographic Details
Main Authors:	Ahmad @ Amat, Faujan, Moghaddam, Mansour Ghaffari, Basri, Mahiran, Abdul Rahman, Mohd Basyaruddin
Format:	Article
Language:	English
Published:	Informa Healthcare 2010
Online Access:	http://psasir.upm.edu.my/id/eprint/14540/ http://psasir.upm.edu.my/id/eprint/14540/1/Enzymatic%20synthesis%20of%20betulinic%20acid%20ester%20as%20an%20anticancer%20agent.pdf

Similar Items

Anticancer activity of 3-O-acylated betulinic acid derivative obtained by enzymatic synthesis
by: Ahmad @ Amat, Faujan, et al.
Published: (2010)

Artificial neural network modeling studies to predict the yield of enzymatic synthesis of betulinic acid ester
by: Moghaddam, Mansour Ghaffari, et al.
Published: (2010)

Spectroscopic data of 3-O-acetyl-betulinic acid: an antitumor reagent
by: Ahmad @ Amat, Faujan, et al.
Published: (2010)

Enzymatic synthesis of betulinic acid ester
by: Chew, Won Yin
Published: (2001)

Investigation on lipase- catalyzed synthesis of 3-Ο-phthalyl- betulinic acid in organic solvent: optimization studies
by: Ahmad, Faujan, et al.
Published: (2009)

Optimization of enzymatic synthesis of 3-O-β-D-glucopyranoside betulinic acid by Novozyme-435
by: Abdu, Hamisu, et al.
Published: (2014)

Lipase-catalyzed esterification of betulinic acid using phthalic anhydride in organic solvent media: study of reaction parameters
by: Moghaddam, Mansour Ghaffari, et al.
Published: (2010)

Response surface methodology as a tool to study the lipase-catalyzed synthesis of betulinic acid ester
by: Yasin, Yamin, et al.
Published: (2008)

Optimized enzymatic synthesis of levulinate ester in solvent-free system
by: Lee, Alice, et al.
Published: (2010)

Enzymatic Synthesis of 3-O-Acylbetulinic Acid Derivatives and Prediction of Acylation Using Response Surface Methodology and Artificial Neural Network Analyses
by: Moghaddam, Mansour Ghaffari
Published: (2010)

Characterization and optimization of enzymatic synthesis of kojic acid esters
by: Mohamad, Rosfarizan
Published: (2009)

Optimization of enzymatic synthesis of palm-based kojic acid ester using response surface methodology
by: Ashaari, Siti Efliza, et al.
Published: (2009)

Enzymatic synthesis and characterization of palm-based kojic acid ester
by: Khamaruddin, Noor Hayati, et al.
Published: (2008)

Formulation of nanoemulsions encapsulated with potential anticancer drug, betulinic acid
by: Abdul Rashid, Nur Nadiah
Published: (2014)

Kinetics of enzymatic synthesis of liquid wax ester from oleic acid and oleyl alcohol
by: Mat Radzi, Salina, et al.
Published: (2010)

Solubility of Betulinic Acid in Microemulsion System:(Part 2).
by: Ismail, Ahmad Zaidi, et al.
Published: (2011)

Microemulsion with ester in mixed surfactants and its association with betulinic acid
by: Wan Mahamod, Wan Rusmawati
Published: (2000)

Enzymatic reaction of betulinic acid with acyl chloride: synthesis of anti-cancer compound / Yamin Yasin
by: Yasin, Yamin
Published: (2011)

Enzymatic synthesis of fatty esters by alkylated lipase
by: Basri, Mahiran, et al.
Published: (1997)

Enzymatic Synthesis of Palm-Based Ferulate Ester as Sunscreen Agent
by: Lim, Sheo Kun
Published: (2006)

Enzymatic Synthesis of Palm Based Amino Acid Esters
by: Soo, Ee Lin
Published: (2003)

Enzymatic synthesis of esters by chiral ionic liquids coated lipase from Candida rugosa
by: Abdul Rahman, Mohd Basyaruddin, et al.
Published: (2008)

Cytotoxic effect of betulinic acid and betulinic acid acetate isolated from Melaleuca cajuput on human myeloid leukemia (HL-60) cell line
by: Faujan, Nur Hana, et al.
Published: (2010)

Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid
by: Tan, Julia M., et al.
Published: (2014)

Enzymatic alcoholysis of triolein to produce wax ester
by: Mat Hadzir, Nursyamsyila, et al.
Published: (2001)

Extraction, isolation and purification of betulinic acid from Melaleuca sp.
by: Ahmad, Faujan, et al.
Published: (2002)

Lipase catalyzed betulinic acid derivatives and its cytotoxic activity / Yamin Yasin and Faujan Ahmad
by: Ahmad, Faujan
Published: (2010)

Preparations of Betulinic Acid Derivatives
by: Mohd Ali, Mohd Tajudin
Published: (2004)

Cytotoxic Effects of Betulinic Acid and its Derivatives on Human Myeloid Leukemia (Hl-60) Cell Line
by: Faujan, Nur Hana
Published: (2008)

Enzymatic synthesis of dilaurylazelate ester for nanocosmeceutical application
by: Khairudin, Nurshafira
Published: (2018)

Optimisation study of large-scale enzymatic synthesis of oleyl oleate, a liquid wax ester, by response surface methodology
by: Mat Radzi, Salina, et al.
Published: (2006)

Optimization of operational conditions for adipate ester synthesis in a stirred tank reactor
by: Chaibakhsh, Naz, et al.
Published: (2010)

Modeling and optimization of lipase-catalyzed production of succinic acid ester using central composite design analysis.
by: Abdul Rahman, Mohd Basyaruddin, et al.
Published: (2011)

Modeling and optimization of lipase-catalyzed production of succinic acid ester using central composite design analysis.
by: Abdul Rahman, Mohd Basyaruddin, et al.
Published: (2011)

Enzymatic synthesis of palm based amino acid surfactants
by: Salleh, Abu Bakar, et al.

Immunomodulatory effects of betulinic acid isolation from the bark of Melaleuca cajuputi
by: Abd Rahman, Mashitoh, et al.
Published: (2012)

Effect of alcohol structure on the optimum condition for Novozym 435-catalyzed synthesis of adipate esters
by: Abdul Rahman, Mohd Basyaruddin, et al.
Published: (2011)

Optimized lipase catalyzed synthesis of adipate ester in a solvent-free system
by: Chaibakhsh, Naz, et al.
Published: (2009)

Optimized Synthesis of Lipase-Catalyzed 3-O-(3',3'-Dimethylsuccinyl)-Betulinic Acid by Immobilised Novozyme 435
by: Gunong @ Mohd Shah, Siti Aminah
Published: (2010)

Optimization of lipase-catalyzed synthesis of xylitol ester by Taguchi robust design method
by: Adnani, Atena, et al.
Published: (2010)