Effects of Morinda citrifolia on early stage of leukaemia in rats
We have studied the effects of Morinda citrifolia on haemogram parameters in rats with early stage of leukaemia. A total of 32 male Sprague Dawley rats were divided into four groups (n=8) namely control, Morinda citrifolia (MC), N-methyl-N-nitrosourea (MNU) and MC+MNU group. Leukaemia induced rats w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14392/ http://psasir.upm.edu.my/id/eprint/14392/1/Effects%20of%20Morinda%20citrifolia%20on%20early%20stage%20of%20leukaemia%20in%20rats.pdf |
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| author | Hamzah, Hazilawati Haron, Nursyuhada Shaari, Mohd Rosly Sithambaram, Shanmugavelu Mohamed Mustapha, Noordin |
| author_facet | Hamzah, Hazilawati Haron, Nursyuhada Shaari, Mohd Rosly Sithambaram, Shanmugavelu Mohamed Mustapha, Noordin |
| author_sort | Hamzah, Hazilawati |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | We have studied the effects of Morinda citrifolia on haemogram parameters in rats with early stage of leukaemia. A total of 32 male Sprague Dawley rats were divided into four groups (n=8) namely control, Morinda citrifolia (MC), N-methyl-N-nitrosourea (MNU) and MC+MNU group. Leukaemia induced rats were provided with died M. citrifolia fruits incorporated into rat diet at a dose of 3000 mg/kg body weight were given daily to the MC and MC+MNU groups. Results showed there were no significant differences in the leukon and erythron parameters in all groups. Although lymphocytosis was not observed in the MNU and MC+MNU groups, examination of the blood morphology showed a typical morphology of leukaemic cell. Seventy-five and sixty percent of rats in the MNU and MC+MNU groups, respectively, had leukaemia. Our results indicate that examination of blood smear provides an important tool for diagnosis of early stage of leukaemia and daily supplementation of M. citrifolia at the dose of 3000 mg/kg reduced the incidence of early stage of leukaemia in rats. |
| first_indexed | 2025-11-15T07:58:13Z |
| format | Article |
| id | upm-14392 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:58:13Z |
| publishDate | 2010 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-143922016-11-21T08:32:35Z http://psasir.upm.edu.my/id/eprint/14392/ Effects of Morinda citrifolia on early stage of leukaemia in rats Hamzah, Hazilawati Haron, Nursyuhada Shaari, Mohd Rosly Sithambaram, Shanmugavelu Mohamed Mustapha, Noordin We have studied the effects of Morinda citrifolia on haemogram parameters in rats with early stage of leukaemia. A total of 32 male Sprague Dawley rats were divided into four groups (n=8) namely control, Morinda citrifolia (MC), N-methyl-N-nitrosourea (MNU) and MC+MNU group. Leukaemia induced rats were provided with died M. citrifolia fruits incorporated into rat diet at a dose of 3000 mg/kg body weight were given daily to the MC and MC+MNU groups. Results showed there were no significant differences in the leukon and erythron parameters in all groups. Although lymphocytosis was not observed in the MNU and MC+MNU groups, examination of the blood morphology showed a typical morphology of leukaemic cell. Seventy-five and sixty percent of rats in the MNU and MC+MNU groups, respectively, had leukaemia. Our results indicate that examination of blood smear provides an important tool for diagnosis of early stage of leukaemia and daily supplementation of M. citrifolia at the dose of 3000 mg/kg reduced the incidence of early stage of leukaemia in rats. Malaysian Medical Association 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14392/1/Effects%20of%20Morinda%20citrifolia%20on%20early%20stage%20of%20leukaemia%20in%20rats.pdf Hamzah, Hazilawati and Haron, Nursyuhada and Shaari, Mohd Rosly and Sithambaram, Shanmugavelu and Mohamed Mustapha, Noordin (2010) Effects of Morinda citrifolia on early stage of leukaemia in rats. Medical Journal of Malaysia, 65 (suppl.B). pp. 135-136. ISSN 0300-5283 http://www.e-mjm.org/2010/Sup_tissue_engineering_content.pdf |
| spellingShingle | Hamzah, Hazilawati Haron, Nursyuhada Shaari, Mohd Rosly Sithambaram, Shanmugavelu Mohamed Mustapha, Noordin Effects of Morinda citrifolia on early stage of leukaemia in rats |
| title | Effects of Morinda citrifolia on early stage of leukaemia in rats |
| title_full | Effects of Morinda citrifolia on early stage of leukaemia in rats |
| title_fullStr | Effects of Morinda citrifolia on early stage of leukaemia in rats |
| title_full_unstemmed | Effects of Morinda citrifolia on early stage of leukaemia in rats |
| title_short | Effects of Morinda citrifolia on early stage of leukaemia in rats |
| title_sort | effects of morinda citrifolia on early stage of leukaemia in rats |
| url | http://psasir.upm.edu.my/id/eprint/14392/ http://psasir.upm.edu.my/id/eprint/14392/ http://psasir.upm.edu.my/id/eprint/14392/1/Effects%20of%20Morinda%20citrifolia%20on%20early%20stage%20of%20leukaemia%20in%20rats.pdf |