Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats.
This study investigated the effect of cacao liquor extract (CLE) on tumor marker enzymes-alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT), glutathione-S-transferase (GST), and glutathione reductase (GR) activities-in plasma and/or liver of hepatocarcinogenic rats, which were induced with...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
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Mary Ann Liebert
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14208/ http://psasir.upm.edu.my/id/eprint/14208/1/Effect%20of%20cacao%20liquor%20extract%20on%20tumor%20marker%20enzymes%20during%20chemical%20hepatocarcinogenesis%20in%20rats.pdf |
| _version_ | 1848842330139787264 |
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| author | Ismail, Amin Koh, B. K. Rahmat, Asmah |
| author_facet | Ismail, Amin Koh, B. K. Rahmat, Asmah |
| author_sort | Ismail, Amin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study investigated the effect of cacao liquor extract (CLE) on tumor marker enzymes-alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT), glutathione-S-transferase (GST), and glutathione reductase (GR) activities-in plasma and/or liver of hepatocarcinogenic rats, which were induced with diethylnitrosamine and 2-acetylaminofluorene. Twenty-nine male Sprague-Dawley rats (weighing 150-330 g) were divided into four groups (n = 6-8): normal control group (N), normal group + CLE (NE), cancer group (C), and cancer group + CLE (CE). Analysis of variance showed significant differences (P < .05) in the specific activities of ALP, GGT, and GST between the C and N groups. However, GR activity for the C group was not significantly different compared with the N group. In the CE group, the specific activities of ALP, GGT, GST, and GR were significantly lower (P < .05) compared with the C group. The findings showed that CLE could lower the activity of tumor marker enzymes of rats during hepatocarcinogenesis. Based on the results obtained, polyphenol compounds present in the cacao liquor, extracted by using ethanol, have the potential in decreasing the severity of hepatocarcinogenesis. |
| first_indexed | 2025-11-15T07:57:25Z |
| format | Article |
| id | upm-14208 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:57:25Z |
| publishDate | 2004 |
| publisher | Mary Ann Liebert |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-142082015-10-02T01:37:49Z http://psasir.upm.edu.my/id/eprint/14208/ Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. Ismail, Amin Koh, B. K. Rahmat, Asmah This study investigated the effect of cacao liquor extract (CLE) on tumor marker enzymes-alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT), glutathione-S-transferase (GST), and glutathione reductase (GR) activities-in plasma and/or liver of hepatocarcinogenic rats, which were induced with diethylnitrosamine and 2-acetylaminofluorene. Twenty-nine male Sprague-Dawley rats (weighing 150-330 g) were divided into four groups (n = 6-8): normal control group (N), normal group + CLE (NE), cancer group (C), and cancer group + CLE (CE). Analysis of variance showed significant differences (P < .05) in the specific activities of ALP, GGT, and GST between the C and N groups. However, GR activity for the C group was not significantly different compared with the N group. In the CE group, the specific activities of ALP, GGT, GST, and GR were significantly lower (P < .05) compared with the C group. The findings showed that CLE could lower the activity of tumor marker enzymes of rats during hepatocarcinogenesis. Based on the results obtained, polyphenol compounds present in the cacao liquor, extracted by using ethanol, have the potential in decreasing the severity of hepatocarcinogenesis. Mary Ann Liebert 2004-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14208/1/Effect%20of%20cacao%20liquor%20extract%20on%20tumor%20marker%20enzymes%20during%20chemical%20hepatocarcinogenesis%20in%20rats.pdf Ismail, Amin and Koh, B. K. and Rahmat, Asmah (2004) Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. Journal of Medicinal Food, 7 (1). pp. 7-12. ISSN 1096-620X; ESSN: 1557-7600 http://online.liebertpub.com/loi/JMF 10.1089/109662004322984635 English |
| spellingShingle | Ismail, Amin Koh, B. K. Rahmat, Asmah Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| title | Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| title_full | Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| title_fullStr | Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| title_full_unstemmed | Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| title_short | Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| title_sort | effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. |
| url | http://psasir.upm.edu.my/id/eprint/14208/ http://psasir.upm.edu.my/id/eprint/14208/ http://psasir.upm.edu.my/id/eprint/14208/ http://psasir.upm.edu.my/id/eprint/14208/1/Effect%20of%20cacao%20liquor%20extract%20on%20tumor%20marker%20enzymes%20during%20chemical%20hepatocarcinogenesis%20in%20rats.pdf |