Diuretic properties of Orthosiphon stamineus Benth.
Ethnopharmacological relevance: Orthosiphon stamineus has been used in traditional medicine for centuries especially to treat diseases of the urinary system. Aim of the study: To investigate the diuretic activity, to elucidate its possible mechanism and to evaluate the renal effects of Ortho...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14116/ http://psasir.upm.edu.my/id/eprint/14116/1/Diuretic%20properties%20of%20Orthosiphon%20stamineus%20Benth.pdf |
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| author | Adam, Yunus M. N., Somchit Sulaiman, Mohd Roslan Abdul Aziz, Nasaruddin Ahmad, Zuraini Abdul, Ahmad Bustamam Zakaria, Zainul Amiruddin |
| author_facet | Adam, Yunus M. N., Somchit Sulaiman, Mohd Roslan Abdul Aziz, Nasaruddin Ahmad, Zuraini Abdul, Ahmad Bustamam Zakaria, Zainul Amiruddin |
| author_sort | Adam, Yunus |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Ethnopharmacological relevance:
Orthosiphon stamineus has been used in traditional medicine for centuries especially to treat diseases of the urinary system.
Aim of the study:
To investigate the diuretic activity, to elucidate its possible mechanism and to evaluate the renal effects of Orthosiphon stamineus extract.
Materials and methods:
Water extracts were administered orally at doses of 5 and 10 mg/kg to Sprague-Dawley rats and the control groups were given commercial diuretic drugs either furosemide or hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4 h. Blood was assayed for glucose, albumin, blood urea nitrogen (BUN) and creatinine.
Results:
O. stamineus extract exhibited dose-dependent diuretic activity. However, excretion of Na+ and Cl- was not markedly elevated, but urinary excretion of K+ was significantly increased. O. stamineus extracts slightly increased the serum BUN, creatinine and blood glucose level. Although these levels were statistically significant when compared to control, these levels were still within normal range.
Conclusions:
O. stamineus exhibited diuretic activity, but was less potent than furosemide and hydrochlorothiazide. Care should be taken when consuming this herb as slight increase of kidney function enzymes was recorded. |
| first_indexed | 2025-11-15T07:57:00Z |
| format | Article |
| id | upm-14116 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:57:00Z |
| publishDate | 2009 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-141162015-11-13T03:54:59Z http://psasir.upm.edu.my/id/eprint/14116/ Diuretic properties of Orthosiphon stamineus Benth. Adam, Yunus M. N., Somchit Sulaiman, Mohd Roslan Abdul Aziz, Nasaruddin Ahmad, Zuraini Abdul, Ahmad Bustamam Zakaria, Zainul Amiruddin Ethnopharmacological relevance: Orthosiphon stamineus has been used in traditional medicine for centuries especially to treat diseases of the urinary system. Aim of the study: To investigate the diuretic activity, to elucidate its possible mechanism and to evaluate the renal effects of Orthosiphon stamineus extract. Materials and methods: Water extracts were administered orally at doses of 5 and 10 mg/kg to Sprague-Dawley rats and the control groups were given commercial diuretic drugs either furosemide or hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4 h. Blood was assayed for glucose, albumin, blood urea nitrogen (BUN) and creatinine. Results: O. stamineus extract exhibited dose-dependent diuretic activity. However, excretion of Na+ and Cl- was not markedly elevated, but urinary excretion of K+ was significantly increased. O. stamineus extracts slightly increased the serum BUN, creatinine and blood glucose level. Although these levels were statistically significant when compared to control, these levels were still within normal range. Conclusions: O. stamineus exhibited diuretic activity, but was less potent than furosemide and hydrochlorothiazide. Care should be taken when consuming this herb as slight increase of kidney function enzymes was recorded. Elsevier 2009-07-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14116/1/Diuretic%20properties%20of%20Orthosiphon%20stamineus%20Benth.pdf Adam, Yunus and M. N., Somchit and Sulaiman, Mohd Roslan and Abdul Aziz, Nasaruddin and Ahmad, Zuraini and Abdul, Ahmad Bustamam and Zakaria, Zainul Amiruddin (2009) Diuretic properties of Orthosiphon stamineus Benth. Journal of Ethnopharmacology, 124 (1). pp. 154-158. ISSN 0378-8741; ESSN: 1872-7573 10.1016/j.jep.2009.04.014 English |
| spellingShingle | Adam, Yunus M. N., Somchit Sulaiman, Mohd Roslan Abdul Aziz, Nasaruddin Ahmad, Zuraini Abdul, Ahmad Bustamam Zakaria, Zainul Amiruddin Diuretic properties of Orthosiphon stamineus Benth. |
| title | Diuretic properties of Orthosiphon stamineus Benth. |
| title_full | Diuretic properties of Orthosiphon stamineus Benth. |
| title_fullStr | Diuretic properties of Orthosiphon stamineus Benth. |
| title_full_unstemmed | Diuretic properties of Orthosiphon stamineus Benth. |
| title_short | Diuretic properties of Orthosiphon stamineus Benth. |
| title_sort | diuretic properties of orthosiphon stamineus benth. |
| url | http://psasir.upm.edu.my/id/eprint/14116/ http://psasir.upm.edu.my/id/eprint/14116/ http://psasir.upm.edu.my/id/eprint/14116/1/Diuretic%20properties%20of%20Orthosiphon%20stamineus%20Benth.pdf |