Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site.
Choline-binding proteins (CBP) have been associated with the pathogenesis of Streptococcus pneumoniae. We screened, using PCR, for the presence of genes (cbpA, D, E, G) encoding these proteins in 34 isolates of pneumococci of known serotypes and penicillin susceptibility from invasive and non-invasi...
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| Format: | Article |
| Language: | English English |
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Cambridge University Press
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/14107/ http://psasir.upm.edu.my/id/eprint/14107/1/Distribution%20of%20CBP%20genes%20in%20Streptococcus%20pneumoniae%20isolates%20in%20relation%20to%20vaccine%20types.pdf |
| _version_ | 1848842302000201728 |
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| author | Mohd Desa, Mohd Nasir Sekaran, Shamala Devi Vadivelu, Jamunarani Navaratnam, Parasakthi |
| author_facet | Mohd Desa, Mohd Nasir Sekaran, Shamala Devi Vadivelu, Jamunarani Navaratnam, Parasakthi |
| author_sort | Mohd Desa, Mohd Nasir |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Choline-binding proteins (CBP) have been associated with the pathogenesis of Streptococcus pneumoniae. We screened, using PCR, for the presence of genes (cbpA, D, E, G) encoding these proteins in 34 isolates of pneumococci of known serotypes and penicillin susceptibility from invasive and non-invasive disease. All isolates harboured cbpD and cbpE whereas cbpA and cbpG were found in 47% and 59% respectively; the latter were more frequent in vaccine-associated types and together accounted for 77% of these isolates. No association was observed with penicillin susceptibility but 85% of non-invasive isolates were positive for these genes. |
| first_indexed | 2025-11-15T07:56:58Z |
| format | Article |
| id | upm-14107 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:56:58Z |
| publishDate | 2008 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-141072015-10-23T06:45:53Z http://psasir.upm.edu.my/id/eprint/14107/ Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. Mohd Desa, Mohd Nasir Sekaran, Shamala Devi Vadivelu, Jamunarani Navaratnam, Parasakthi Choline-binding proteins (CBP) have been associated with the pathogenesis of Streptococcus pneumoniae. We screened, using PCR, for the presence of genes (cbpA, D, E, G) encoding these proteins in 34 isolates of pneumococci of known serotypes and penicillin susceptibility from invasive and non-invasive disease. All isolates harboured cbpD and cbpE whereas cbpA and cbpG were found in 47% and 59% respectively; the latter were more frequent in vaccine-associated types and together accounted for 77% of these isolates. No association was observed with penicillin susceptibility but 85% of non-invasive isolates were positive for these genes. Cambridge University Press 2008-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14107/1/Distribution%20of%20CBP%20genes%20in%20Streptococcus%20pneumoniae%20isolates%20in%20relation%20to%20vaccine%20types.pdf Mohd Desa, Mohd Nasir and Sekaran, Shamala Devi and Vadivelu, Jamunarani and Navaratnam, Parasakthi (2008) Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. Epidemiology and Infection, 136 (7). pp. 940-942. ISSN 0950-2688; ESSN: 1469-4409 10.1017/S0950268807009363 English |
| spellingShingle | Mohd Desa, Mohd Nasir Sekaran, Shamala Devi Vadivelu, Jamunarani Navaratnam, Parasakthi Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| title | Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| title_full | Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| title_fullStr | Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| title_full_unstemmed | Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| title_short | Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| title_sort | distribution of cbp genes in streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site. |
| url | http://psasir.upm.edu.my/id/eprint/14107/ http://psasir.upm.edu.my/id/eprint/14107/ http://psasir.upm.edu.my/id/eprint/14107/1/Distribution%20of%20CBP%20genes%20in%20Streptococcus%20pneumoniae%20isolates%20in%20relation%20to%20vaccine%20types.pdf |