Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration.
We report a case of systemic diffuse large B-cell lymphoma presenting with extensive infiltration of the skin. A 56-year-old woman presented with a two-month history of pruritic erythematous plaques and nodules over the neck, trunk and upper limbs. She also had night sweats, weight loss, lethargy an...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Singapore Medical Association
2012
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/14073/ http://psasir.upm.edu.my/id/eprint/14073/1/Diffuse%20large%20B.pdf |
| _version_ | 1848842292264173568 |
|---|---|
| author | Shamsudin, Norashikin Chang, Choong Chor |
| author_facet | Shamsudin, Norashikin Chang, Choong Chor |
| author_sort | Shamsudin, Norashikin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | We report a case of systemic diffuse large B-cell lymphoma presenting with extensive infiltration of the skin. A 56-year-old woman presented with a two-month history of pruritic erythematous plaques and nodules over the neck, trunk and upper limbs. She also had night sweats, weight loss, lethargy and reduced effort tolerance. Systemic examination revealed a pale, ill appearance with hepatosplenomegaly and lymphadenopathy. Blood investigations showed pancytopenia (haemoglobin 6.3 g/dL, total white cell count 3.0 × 109/L, platelet count 138 × 109/L) with a few suspicious mononuclear cells and a mildly elevated lactate dehydrogenase level (478 U/L). Skin biopsy demonstrated diffuse sheets and nodular infiltrates of CD20 and CD79a positive neoplastic cells in the dermis and subcutis. Computed tomography revealed multiple cervical, axillary, mediastinal, para-aortic and mesenteric lymph nodes. Bone marrow aspiration and trephine biopsy confirmed marrow involvement by non-Hodgkin's lymphoma. The patient was treated with chemotherapy, which resulted in resolution of the skin lesions. |
| first_indexed | 2025-11-15T07:56:49Z |
| format | Article |
| id | upm-14073 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:56:49Z |
| publishDate | 2012 |
| publisher | Singapore Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-140732016-02-17T02:21:32Z http://psasir.upm.edu.my/id/eprint/14073/ Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. Shamsudin, Norashikin Chang, Choong Chor We report a case of systemic diffuse large B-cell lymphoma presenting with extensive infiltration of the skin. A 56-year-old woman presented with a two-month history of pruritic erythematous plaques and nodules over the neck, trunk and upper limbs. She also had night sweats, weight loss, lethargy and reduced effort tolerance. Systemic examination revealed a pale, ill appearance with hepatosplenomegaly and lymphadenopathy. Blood investigations showed pancytopenia (haemoglobin 6.3 g/dL, total white cell count 3.0 × 109/L, platelet count 138 × 109/L) with a few suspicious mononuclear cells and a mildly elevated lactate dehydrogenase level (478 U/L). Skin biopsy demonstrated diffuse sheets and nodular infiltrates of CD20 and CD79a positive neoplastic cells in the dermis and subcutis. Computed tomography revealed multiple cervical, axillary, mediastinal, para-aortic and mesenteric lymph nodes. Bone marrow aspiration and trephine biopsy confirmed marrow involvement by non-Hodgkin's lymphoma. The patient was treated with chemotherapy, which resulted in resolution of the skin lesions. Singapore Medical Association 2012-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/14073/1/Diffuse%20large%20B.pdf Shamsudin, Norashikin and Chang, Choong Chor (2012) Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. Singapore Medical Journal, 53 (9). e198-e200. ISSN 0037-5675 English |
| spellingShingle | Shamsudin, Norashikin Chang, Choong Chor Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. |
| title | Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. |
| title_full | Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. |
| title_fullStr | Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. |
| title_full_unstemmed | Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. |
| title_short | Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration. |
| title_sort | diffuse large b-cell lymphoma presenting with extensive cutaneous infiltration. |
| url | http://psasir.upm.edu.my/id/eprint/14073/ http://psasir.upm.edu.my/id/eprint/14073/1/Diffuse%20large%20B.pdf |