Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chlor...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13851/ |
| _version_ | 1848842228579958784 |
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| author | Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf |
| author_facet | Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf |
| author_sort | Shaari, Khozirah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells. |
| first_indexed | 2025-11-15T07:55:48Z |
| format | Article |
| id | upm-13851 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:55:48Z |
| publishDate | 2009 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-138512013-11-06T03:37:17Z http://psasir.upm.edu.my/id/eprint/13851/ Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells. MDPI 2009 Article PeerReviewed Shaari, Khozirah and Kee, Cheng Ling and Mat Rashid, Zalilawati and Tan, Pei Jean and Abas, Faridah and Mohd Raof, Salahudin and Zainal, Zurina and Lajis, Nordin and Mohamad, Habsah and Ali, Abdul Manaf (2009) Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Marine Drugs, 7 (1). pp. 1-8. ISSN 1660-3397 10.3390/md7010001 English |
| spellingShingle | Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf Cytotoxic Aaptamines from Malaysian Aaptos aaptos. |
| title | Cytotoxic Aaptamines from Malaysian Aaptos aaptos. |
| title_full | Cytotoxic Aaptamines from Malaysian Aaptos aaptos. |
| title_fullStr | Cytotoxic Aaptamines from Malaysian Aaptos aaptos. |
| title_full_unstemmed | Cytotoxic Aaptamines from Malaysian Aaptos aaptos. |
| title_short | Cytotoxic Aaptamines from Malaysian Aaptos aaptos. |
| title_sort | cytotoxic aaptamines from malaysian aaptos aaptos. |
| url | http://psasir.upm.edu.my/id/eprint/13851/ http://psasir.upm.edu.my/id/eprint/13851/ |