Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats
This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Ma...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13684/ http://psasir.upm.edu.my/id/eprint/13684/1/Comparison%20of%20cardiovascular%20protective%20effects%20of%20tropical%20seaweeds%2C%20Kappaphycus%20alvarezii%2C%20Caulerpa%20lentillifera%2C%20and%20Sargassum%20polycystum%2C%20on%20high-%20cholesterolhigh-fat%20diet%20in%20rats.pdf |
| _version_ | 1848842179865214976 |
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| author | Matanjun, Patricia Mohamed, Suhaila Syed Muhammad, Sharifah Kharidah Mohamed Mustapha, Noordin |
| author_facet | Matanjun, Patricia Mohamed, Suhaila Syed Muhammad, Sharifah Kharidah Mohamed Mustapha, Noordin |
| author_sort | Matanjun, Patricia |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260–300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (−11.4% to −18.5%), LDL-C (−22% to −49.3%), and TG (−33.7% to −36.1%) levels and significantly increased HDL-C levels (16.3–55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats. |
| first_indexed | 2025-11-15T07:55:01Z |
| format | Article |
| id | upm-13684 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:55:01Z |
| publishDate | 2010 |
| publisher | Mary Ann Liebert |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-136842016-04-18T08:33:58Z http://psasir.upm.edu.my/id/eprint/13684/ Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats Matanjun, Patricia Mohamed, Suhaila Syed Muhammad, Sharifah Kharidah Mohamed Mustapha, Noordin This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260–300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (−11.4% to −18.5%), LDL-C (−22% to −49.3%), and TG (−33.7% to −36.1%) levels and significantly increased HDL-C levels (16.3–55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats. Mary Ann Liebert 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13684/1/Comparison%20of%20cardiovascular%20protective%20effects%20of%20tropical%20seaweeds%2C%20Kappaphycus%20alvarezii%2C%20Caulerpa%20lentillifera%2C%20and%20Sargassum%20polycystum%2C%20on%20high-%20cholesterolhigh-fat%20diet%20in%20rats.pdf Matanjun, Patricia and Mohamed, Suhaila and Syed Muhammad, Sharifah Kharidah and Mohamed Mustapha, Noordin (2010) Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats. Journal of Medicinal Food, 13 (4). pp. 792-800. ISSN 1096-620X; ESSN: 1557-7600 http://online.liebertpub.com/doi/abs/10.1089/jmf.2008.1212 10.1089/jmf.2008.1212 |
| spellingShingle | Matanjun, Patricia Mohamed, Suhaila Syed Muhammad, Sharifah Kharidah Mohamed Mustapha, Noordin Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| title | Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| title_full | Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| title_fullStr | Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| title_full_unstemmed | Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| title_short | Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| title_sort | comparison of cardiovascular protective effects of tropical seaweeds, kappaphycus alvarezii, caulerpa lentillifera, and sargassum polycystum, on high- cholesterol/high-fat diet in rats |
| url | http://psasir.upm.edu.my/id/eprint/13684/ http://psasir.upm.edu.my/id/eprint/13684/ http://psasir.upm.edu.my/id/eprint/13684/ http://psasir.upm.edu.my/id/eprint/13684/1/Comparison%20of%20cardiovascular%20protective%20effects%20of%20tropical%20seaweeds%2C%20Kappaphycus%20alvarezii%2C%20Caulerpa%20lentillifera%2C%20and%20Sargassum%20polycystum%2C%20on%20high-%20cholesterolhigh-fat%20diet%20in%20rats.pdf |